P2X1 Inhibitors

NF 449 is a selective antagonist of P2X1 receptors, exhibiting a unique ability to inhibit ion channel activity. Its distinct molecular structure allows for specific interactions with the receptor's binding site, effectively blocking cation influx. The compound's kinetics reveal a competitive inhibition profile, with a notable impact on receptor desensitization. This modulation of purinergic signaling pathways highlights NF 449's role in influencing cellular excitability and neurotransmission.

NF 023 is a potent modulator of P2X1 receptors, characterized by its ability to selectively alter receptor conformations. Its unique binding affinity facilitates a distinct allosteric interaction, leading to a reduction in ion permeability. The compound exhibits rapid kinetics, influencing the receptor's activation threshold and altering downstream signaling cascades. This specificity in receptor modulation underscores its potential to impact various physiological processes linked to purinergic signaling.

Brilliant Blue G is a selective P2X7 receptor antagonist that can indirectly affect P2X1 function by modulating purinergic signaling.

PPADS tetrasodium salt, anhydrous, is a selective antagonist of P2X1 receptors, known for its ability to disrupt ATP-mediated ion channel activity. Its unique structural features enable it to bind with high affinity, stabilizing inactive receptor conformations. This interaction effectively inhibits calcium influx, modulating cellular responses. The compound's distinct physicochemical properties contribute to its role in influencing receptor dynamics and altering purinergic signaling pathways.

Adenosine 2',5'-diphosphate sodium salt acts as a potent modulator of P2X1 receptors, facilitating the regulation of ion channel activity through its unique binding characteristics. Its molecular structure allows for specific interactions with receptor sites, promoting conformational changes that influence ion permeability. This compound exhibits distinct reaction kinetics, impacting the rate of ATP hydrolysis and subsequent signaling cascades, thereby playing a crucial role in purinergic transmission.

A-317491 is a selective P2X3 and P2X2/3 receptor antagonist that can indirectly affect P2X1 function by modulating purinergic signaling.

NF 279 is a selective P2X1 receptor antagonist that exhibits unique binding dynamics, influencing receptor conformation and ion flow. Its molecular interactions are characterized by a high affinity for the receptor, leading to altered signaling pathways. The compound's kinetic profile reveals a distinct modulation of calcium influx, which can affect downstream cellular responses. This specificity in receptor interaction highlights its role in purinergic signaling modulation.

Ro 0437626 is a potent P2X1 receptor modulator that demonstrates unique allosteric effects on receptor activity. Its binding induces conformational changes that enhance or inhibit ion channel opening, thereby influencing intracellular calcium levels. The compound exhibits rapid kinetics, allowing for swift modulation of receptor responses. Additionally, its selective interaction with the P2X1 receptor underscores its potential to fine-tune purinergic signaling pathways in various cellular contexts.

MRS 2159 is a selective antagonist of the P2X1 receptor, characterized by its ability to disrupt ATP-mediated signaling. It engages in specific molecular interactions that stabilize the inactive state of the receptor, effectively blocking ion flow. This compound exhibits a unique binding profile, leading to altered receptor dynamics and influencing downstream signaling cascades. Its rapid dissociation kinetics allow for precise modulation of receptor activity, making it a valuable tool for studying purinergic mechanisms.

RB-2 is a non-selective P2 receptor antagonist that can indirectly affect P2X1 function by blocking ATP-induced responses.