Date published: 2026-1-31

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ro 0437626 (CAS 134362-79-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Application:
Ro 0437626 is a P2X1 purinergic receptor antagonist
CAS Number:
134362-79-1
Purity:
≥98%
Molecular Weight:
525.66
Molecular Formula:
C27H35N5O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ro 0437626 functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the inhibition of certain cellular processes, which is of interest in various experimental applications. Ro 0437626′s mechanism of action involves interfering with the phosphorylation of key proteins, thereby modulating their activity and impacting cellular responses. This specific mechanism of action makes Ro 0437626 valuable for investigating the role of the targeted enzyme in various cellular processes and signaling pathways.


Ro 0437626 (CAS 134362-79-1) References

  1. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry.  |  Harper, MT., et al. 2010. J Thromb Haemost. 8: 1604-13. PMID: 20345709
  2. Pharmacochemistry of the platelet purinergic receptors.  |  Jacobson, KA., et al. 2011. Purinergic Signal. 7: 305-24. PMID: 21484092
  3. Development of a comprehensive set of P2 receptor pharmacological research compounds.  |  Felix, RA., et al. 2012. Purinergic Signal. 8: 101-12. PMID: 22052555
  4. Discovery of purinergic signalling, the initial resistance and current explosion of interest.  |  Burnstock, G. 2012. Br J Pharmacol. 167: 238-55. PMID: 22537142
  5. Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets.  |  Sage, SO., et al. 2013. Physiol Rep. 1: e00085. PMID: 24303163
  6. P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages.  |  Layhadi, JA. and Fountain, SJ. 2017. Int J Mol Sci. 18: PMID: 29077063
  7. ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages.  |  Layhadi, JA., et al. 2018. J Immunol. 200: 1159-1168. PMID: 29255078
  8. P2X1 receptor blockers reduce the number of circulating thrombocytes and the overall survival of urosepsis with haemolysin-producing Escherichia coli.  |  Skals, M., et al. 2019. Purinergic Signal. 15: 265-276. PMID: 31129780
  9. ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation.  |  Layhadi, JA. and Fountain, SJ. 2019. Int J Mol Sci. 20: PMID: 31618941
  10. P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion.  |  Soare, AY., et al. 2020. J Virol. 94: PMID: 31852781

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ro 0437626, 1 mg

sc-204239
1 mg
$151.00

Ro 0437626, 5 mg

sc-204239B
5 mg
$749.00