Molecular structure of MRS 2159
MRS 2159
See product citations (1)
Application:
MRS 2159 is a potent P2X1 purinoceptor antagonist
Purity:
>98%
Molecular Weight:
461.21
Molecular Formula:
C15H11N3O8PNa3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MRS 2159 is a potent P2X1 purinoceptor antagonist. The P2Y1 receptor is a G protein-coupled receptor (GPCR) that responds to the extracellular nucleotide ADP (adenosine diphosphate). It plays a critical role in various physiological processes, including platelet aggregation, vascular smooth muscle contraction, and neurotransmission. As a selective P2Y1 receptor antagonist, MRS 2159 is utilized in scientific research to study the role of P2Y1 and purinergic signaling. By inhibiting the activity of the P2Y1 receptor, MRS 2159 helps in dissecting the specific contributions of this receptor in complex physiological and pathological processes.
MRS 2159 References
- Potentiation of platelet activation through the stimulation of P2X1 receptors. | Erhardt, JA., et al. 2003. J Thromb Haemost. 1: 2626-35. PMID: 14675100
- Ex vivo evaluation of erythrocytosis-enhanced platelet thrombus formation using the cone and plate(let) analyzer: effect of platelet antagonists. | Peerschke, EI., et al. 2004. Br J Haematol. 127: 195-203. PMID: 15461626
- ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. | Lee, YJ., et al. 2005. Am J Physiol Cell Physiol. 289: C1268-76. PMID: 16014705
- Role of ATP in DNA synthesis of renal proximal tubule cells: involvement of calcium, MAPKs, and CDKs. | Lee, YJ. and Han, HJ. 2006. Am J Physiol Renal Physiol. 291: F98-106. PMID: 16418299
- Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21(WAF1/Cip1) and p27(Kip1) expression in primary cultured renal proximal tubule cells: role of PI3K and Akt signaling. | Lee, YJ., et al. 2006. J Cell Physiol. 209: 802-10. PMID: 16972266
- Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. | Donnelly-Roberts, DL., et al. 2009. Br J Pharmacol. 157: 1203-14. PMID: 19558545
- alpha(1)-acid glycoprotein (AGP)-induced platelet shape change involves the Rho/Rho kinase signalling pathway. | Gunnarsson, P., et al. 2009. Thromb Haemost. 102: 694-703. PMID: 19806255
- Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y1 and P2Y12 receptor activation. | Kälvegren, H., et al. 2010. Thromb Haemost. 103: 398-407. PMID: 20024498
- Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry. | Harper, MT., et al. 2010. J Thromb Haemost. 8: 1604-13. PMID: 20345709
- The P2X1 receptor and platelet function. | Mahaut-Smith, MP., et al. 2011. Purinergic Signal. 7: 341-56. PMID: 21484087
- Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists. | Jung, KY., et al. 2013. Bioorg Med Chem. 21: 2643-50. PMID: 23510563
- Inhibition of Ecto-Apyrase and Ecto-ATPase by Pyridoxal Phosphate-Related Compounds. | Hoffmann, C., et al. 2000. Drug Dev Res. 51: 151-158. PMID: 27134333
- Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. | Brown, SG., et al. 2001. Drug Dev Res. 53: 281-291. PMID: 27134334
- Modulators of 14-3-3 Protein-Protein Interactions. | Stevers, LM., et al. 2018. J Med Chem. 61: 3755-3778. PMID: 28968506
Inhibitor of:
P2X1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRS 2159, 5 mg | sc-301175 | 5 mg | $204.00 | |||
MRS 2159, 25 mg | sc-301175A | 25 mg | $322.00 |