OXA1L Inhibitors
Chemical inhibitors of OXA1L target the protein's role within the mitochondrial inner membrane, where it is involved in the insertion of nascent proteins. CCCP, known as Carbonyl cyanide m-chlorophenyl hydrazone, directly inhibits OXA1L by compromising mitochondrial membrane potential, a critical driver of OXA1L's function in protein insertion. Similarly, Valinomycin disrupts mitochondrial function by altering ionic balance and collapsing the electrochemical gradient, indirectly inhibiting OXA1L. Oligomycin and Aurovertin B both target ATP synthase, with the resultant effect of altering mitochondrial membrane potential, thus hindering OXA1L's ability to maintain its role in mitochondrial protein homeostasis. Antimycin A and Atovaquone, which inhibit complex III, and Rotenone and Piericidin A, which inhibit complex I of the electron transport chain, lead to altered mitochondrial membrane potentials. This, in turn, disrupts the function of OXA1L by impacting its protein insertion activity.
Other inhibitors such as Concanamycin A and Bongkrekic acid affect the proton gradient and the mitochondrial permeability transition pore, respectively. These changes can lead to inhibition of OXA1L by affecting the mitochondrial membrane potential essential for its activity. Carboxin and Zinc pyrithione both inhibit complex II, leading to reduced electron transport, which is closely tied to the mitochondrial membrane potential and essential for OXA1L's function. By targeting these various aspects of mitochondrial function, these chemical inhibitors disrupt the delicate balance of conditions required for OXA1L to facilitate the proper insertion of proteins into the mitochondrial inner membrane, leading to its functional inhibition.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP disrupts mitochondrial membrane potential, directly inhibiting the function of OXA1L by impeding its role in the insertion of proteins into the mitochondrial inner membrane. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III, which can lead to a buildup of reactive oxygen species that indirectly inhibit OXA1L by oxidative damage to mitochondrial membranes where OXA1L functions. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin blocks ATP synthase in mitochondria, which can indirectly inhibit OXA1L by altering the mitochondrial membrane potential necessary for its function in protein insertion. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aurovertin B inhibits mitochondrial ATP synthase, which can lead to a reduced mitochondrial membrane potential, thereby inhibiting the activity of OXA1L in the mitochondrial inner membrane. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin acts as a potassium ionophore, disturbing the ionic balance across the mitochondrial membrane and thus indirectly inhibiting OXA1L by collapsing the electrochemical gradient it relies on. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is a V-ATPase inhibitor that can disrupt the proton gradient across mitochondrial membranes, thereby indirectly inhibiting the function of OXA1L in maintaining mitochondrial protein homeostasis. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $400.00 | 10 | |
Bongkrekic acid prevents the opening of the mitochondrial permeability transition pore, which can affect the mitochondrial membrane potential and thereby inhibit OXA1L's role in protein insertion into the inner membrane. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits mitochondrial complex II, leading to reduced electron transport and an altered membrane potential, which can inhibit OXA1L function by impacting its protein insertion activity. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A inhibits complex I of the electron transport chain, which can lead to an altered mitochondrial membrane potential, thus indirectly inhibiting OXA1L's function in the mitochondrial inner membrane. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor, which would disrupt the electron transport chain, affecting the mitochondrial membrane potential and thus inhibiting OXA1L's role in the mitochondrial protein insertion process. | ||||||