Molecular structure of Piericidin A, CAS Number: 2738-64-9
Piericidin A (CAS 2738-64-9)
See product citations (24)
Alternate Names:
Piericidin A is also known as AR-054.
Application:
Piericidin A is an antibiotic agent and a member of the Class I inhibitors that acts as an effective inhibitor of Complex I.
CAS Number:
2738-64-9
Purity:
≥95%
Molecular Weight:
415.57
Molecular Formula:
C25H37NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Piericidin A, a potent antibiotic recognized for its capacity to inhibit bacterial and mitochondrial type I NADH-ubiquinone oxidoreductases (Complex I), plays a role in studying mitochondrial functions and dynamics. It acts by impeding the electron transfer process for cellular energy production, specifically targeting NADH dehydrogenase. Piericidin A′s unique mode of action involves blocking the electron transfer by preventing the translocation of protons induced by NADH in the NADH-endogenous ubiquinone reductase reaction. This inhibition is facilitated through its binding near the interface of NUOD and NUOB within Complex I, providing useful for probing the intricate mechanisms of mitochondrial respiration and bioenergetics. Researchers value Piericidin A for its specificity and effectiveness, making it an essential component in the toolkit for studying cellular respiration and its implications in various bioenergetic processes.
Piericidin A (CAS 2738-64-9) References
- -->H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. | Galkin, AS., et al. 1999. FEBS Lett. 451: 157-61. PMID: 10371157
- Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. | Prieur, I., et al. 2001. Biochim Biophys Acta. 1504: 173-8. PMID: 11245783
- Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. | Hwang, JH., et al. 2008. J Cell Physiol. 215: 243-50. PMID: 17941090
- Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same. | Ramsay, RR., et al. 1991. Biochem J. 273(Pt 2): 481-4. PMID: 1991043
- Piericidin A aggravates Tau pathology in P301S transgenic mice. | Höllerhage, M., et al. 2014. PLoS One. 9: e113557. PMID: 25437199
- Correction: Piericidin A aggravates tau pathology in P301S transgenic mice. | ,. 2015. PLoS One. 10: e0122907. PMID: 25812110
- Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP01532 for the control of potato soft rot caused by Erwinia carotovora subsp. atroseptica. | Kang, JE., et al. 2016. Microbiol Res. 184: 32-41. PMID: 26856451
- Propene as an Atom-Economical Linchpin for Concise Total Synthesis of Polyenes: Piericidin A. | Trost, BM. and Gholami, H. 2018. J Am Chem Soc. 140: 11623-11626. PMID: 30173519
- Piericidin A: a new inhibitor of mitochondrial electron transport. | Hall, C., et al. 1966. Biochem Biophys Res Commun. 25: 373-7. PMID: 4290528
- Piericidin A and inhibition of respiratory chain activity in Escherichia coli K12. | Snoswell, AM. and Cox, GB. 1968. Biochim Biophys Acta. 162: 455-8. PMID: 4300595
- Mode of action of piericidin A on the phosphorylating respiratory chains. | Kosaka, T. and Ishikawa, S. 1968. J Biochem. 63: 506-13. PMID: 4302092
- Non-haem iron and the dissociation of piericidin A sensitivity from site 1 energy conservation in mitochondria from Torulopsis utilis. | Clegg, RA. and Garland, PB. 1971. Biochem J. 124: 135-51. PMID: 4331255
- Effects of piericidin A and amytal on the energy-linked swelling of rat liver mitochondria. | Bhuvaneswaran, C. and Dakshinamurti, K. 1972. Experientia. 28: 777-8. PMID: 4658851
- Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. | Friedrich, T., et al. 1994. Eur J Biochem. 219: 691-8. PMID: 8307034
- The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors. | Darrouzet, E., et al. 1998. FEBS Lett. 431: 34-8. PMID: 9684860
Inhibitor of:
1190007I07Rik, 2900010M23Rik, ATP5J2, ATPAF1, BCS1L, C8orf38, COQ5, COX8b, Cytochrome c oxidase (COX), EG623286, ETFDH, Grim19, H6PD, HRPAP20, LYRM2, LYRM4, LYRM5, Magmas, Mimitin, MP68, MT-ND (mitochondrial NADH dehydrogenase), Mtch2, MTO1, ND1, ND2, ND4, ND6, NDH II, NDUFA (NADH:ubiquinone oxidoreductase subunit), NDUFAB1, NDUFB (NADH:ubiquinone oxidoreductase subunit), NDUFB10, NDUFB2, NDUFB3, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFC1, NDUFS, NDUFS5, NNT, OXA1L, PET100, QCR10, RFESD, SCAF1, Tim22, Tom7, and WBSCR18.Activator of:
ClpP, MTFmt, and UBA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Piericidin A, 2 mg | sc-202287 | 2 mg | $291.00 |