OTTMUSG00000018981 Inhibitors
The inhibition of ovary testis transcribed isoform X1 is achieved through a variety of mechanisms, each targeting specific cellular pathways and processes that are crucial for the protein's functional activity. Staurosporine, as a kinase inhibitor, prevents the phosphorylation of ovary testis transcribed isoform X1, a process likely essential for its activation or modification. Similarly, LY294002 and Wortmannin, both PI3K inhibitors, disrupt signaling pathways that ovary testis transcribed isoform X1 may rely on for its activity. The inhibition of the PI3K pathway can lead to a cascade of effects, culminating in the functional inhibition of ovary testis transcribed isoform X1. Rapamycin, targeting the mTOR pathway, affects protein synthesis and cellular growth processes, which are potentially vital for the functional expression or post-translational modifications of ovary testis transcribed isoform X1. PD98059 and U0126, both targeting the MAPK/ERK pathway, and SB203580 and SP600125, targeting the p38 MAPK and JNK pathways respectively, impede signaling routes that may regulate or influence the activity of ovary testis transcribed isoform X1. The MAPK pathways, known for their roles in stress responses and cellular regulation, are integral to the functional regulation of many proteins.
Tyrosine kinase inhibitors like Dasatinib, Erlotinib, Imatinib, and Lapatinib, each target different kinases within the cellular signaling networks. These kinases, including BCR-ABL, c-Kit, PDGFR, EGFR, and HER2/neu, are pivotal in various signaling pathways that can regulate or affect the activity of ovary testis transcribed isoform X1. The inhibition of these kinases leads to a reduction in the functional activity of ovary testis transcribed isoform X1 by disrupting the signaling cascades that are crucial for its functional state. Thus, the collective action of these inhibitors, through their specific targets, contributes to the functional inhibition of ovary testis transcribed isoform X1, demonstrating the intricate interplay between cellular signaling pathways and protein functionality.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Ovary testis transcribed isoform X1, being a protein that potentially undergoes phosphorylation, can be inhibited in its function by staurosporine's action on kinases that phosphorylate it, thereby preventing its activation or functional modification through phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. The PI3K pathway is crucial for many cellular processes, including those that ovary testis transcribed isoform X1 might be involved in. By inhibiting PI3K, LY294002 can hinder the downstream signaling that might be essential for the functional activity of ovary testis transcribed isoform X1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Since the mTOR pathway is involved in protein synthesis and cell growth, its inhibition can affect the function of proteins like ovary testis transcribed isoform X1, which may rely on mTOR-mediated pathways for its functional expression or post-translational modifications. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which is part of the MAPK/ERK pathway. This pathway might be involved in the regulation or function of ovary testis transcribed isoform X1. Inhibition of MEK by PD98059 can lead to reduced ERK activity, potentially inhibiting the function of ovary testis transcribed isoform X1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. The p38 MAPK pathway is involved in stress responses and may regulate the activity of proteins like ovary testis transcribed isoform X1. Inhibiting p38 MAPK with SB203580 can lead to a decrease in the functional activity of ovary testis transcribed isoform X1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK. The JNK pathway is implicated in various cellular processes, including those in which ovary testis transcribed isoform X1 might play a role. By inhibiting JNK, SP600125 can reduce the functional activity of ovary testis transcribed isoform X1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, key components of the MAPK/ERK pathway. This pathway's inhibition by U0126 can lead to reduced activity of downstream targets, potentially including ovary testis transcribed isoform X1, thereby inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. By inhibiting PI3K, wortmannin can disrupt signaling pathways essential for the function of proteins like ovary testis transcribed isoform X1, leading to its functional inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor. Tyrosine kinases are involved in various signaling pathways, including those that could regulate or affect the activity of ovary testis transcribed isoform X1. Inhibition of these kinases by dasatinib can lead to reduced activity of ovary testis transcribed isoform X1. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. EGFR signaling can be important for the function of proteins like ovary testis transcribed isoform X1. Inhibiting EGFR with erlotinib can lead to reduced activity of ovary testis transcribed isoform X1. | ||||||