OTTMUSG00000016887 Activators
H2al1k, a member of the histone cluster 2 family, plays a crucial role in regulating chromatin structure and gene expression. It is involved in modulating the accessibility of DNA to various transcription factors and regulatory proteins, influencing gene transcription. The activation of H2al1k is essential for its functional role in gene regulation. Several chemicals have been identified that can activate H2al1k, either directly or indirectly. Direct activators like Forskolin and Phorbol 12-myristate 13-acetate (PMA) directly phosphorylate and activate H2al1k, enhancing its functional role in chromatin remodeling and gene expression. Sodium orthovanadate inhibits tyrosine phosphatases, leading to sustained phosphorylation and activation of H2al1k. Indirect activators such as Resveratrol and Sodium butyrate influence H2al1k activation by modulating the activity of enzymes like SIRT1 and histone deacetylases (HDACs). These compounds affect the acetylation status of histones associated with H2al1k, promoting its functional activation in gene regulation.
Additionally, chemicals like 5-Aza-2'-deoxycytidine and Trichostatin A can modify the epigenetic landscape by demethylating DNA or inhibiting HDACs, respectively, resulting in increased transcription of H2al1k and functional activation. Furthermore, compounds like Thapsigargin and Wortmannin indirectly activate H2al1k by influencing cellular pathways associated with stress responses and signaling cascades. In summary, H2al1k is a key player in chromatin remodeling and gene regulation, and its activation is influenced by various chemicals through both direct and indirect mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA directly activates protein kinase C (PKC), which can phosphorylate and activate H2al1k. This direct activation leads to functional changes in H2al1k's activity, making it more active in its role. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate functions as a tyrosine phosphatase inhibitor, preventing the dephosphorylation of H2al1k. This inhibition results in sustained phosphorylation and activation of H2al1k, leading to functional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates H2al1k indirectly by modulating SIRT1 activity. SIRT1 is a NAD+-dependent deacetylase that can deacetylate H2al1k, rendering it more functionally active. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as a histone deacetylase (HDAC) inhibitor, increasing the acetylation of histones, including those associated with H2al1k. This acetylation enhances H2al1k's accessibility to DNA, promoting its functional activation in gene regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor. By demethylating the promoter region of H2al1k gene, it increases the transcription of H2al1k, leading to elevated protein levels and functional activation of H2al1k. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor, enhancing histone acetylation, including those associated with H2al1k. This acetylation promotes chromatin accessibility and transcriptional activation of H2al1k, resulting in its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces endoplasmic reticulum (ER) stress, leading to the activation of the unfolded protein response (UPR) pathway. The UPR pathway can modulate various cellular processes, including gene expression, and can indirectly activate H2al1k through these cellular responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin functions as a phosphoinositide 3-kinase (PI3K) inhibitor, disrupting the PI3K/Akt signaling pathway. This disruption indirectly activates H2al1k, as the PI3K/Akt pathway can phosphorylate and inactivate H2al1k. Wortmannin's action leads to functional activation of H2al1k. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) can indirectly activate H2al1k by inhibiting inositol trisphosphate receptor (IP3R) channels. This inhibition disrupts calcium signaling pathways, which can influence H2al1k activation through calcium-dependent pathways, leading to functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates H2al1k indirectly by binding to retinoic acid receptors (RARs), which can modulate gene expression, including genes associated with H2al1k regulation. This modulation leads to an increase in H2al1k levels and its functional activation in transcriptional regulation. | ||||||