OTTMUSG00000016790 Activators
Histone cluster 2 family member (H2al1e) plays a pivotal role in the intricate orchestration of gene expression and chromatin dynamics within the cell. As a variant of histone proteins, H2al1e is part of the histone octamer that constitutes the core of nucleosomes, around which DNA is wrapped to form chromatin. Unlike canonical histones, H2al1e exhibits unique characteristics that influence the regulation of gene transcription. It serves as a critical determinant in the packaging of DNA into chromatin, where it interacts with various transcription factors and other regulatory proteins to modulate gene expression. The activation of H2al1e involves a complex interplay of molecular mechanisms that ultimately lead to enhanced gene expression. These mechanisms include post-translational modifications such as acetylation, phosphorylation, and methylation, as well as interactions with specific cofactors and coactivators. Acetylation of H2al1e at specific lysine residues promotes an open chromatin structure, facilitating the binding of transcription factors to target genes and thus enhancing gene activation. Additionally, phosphorylation of H2al1e can modulate its interaction with various proteins, further influencing its role in gene regulation. H2al1e's activation also relies on interactions with coactivators, which can recruit RNA polymerase and other transcriptional machinery to specific genomic regions, promoting transcription initiation.
In summary, histone cluster 2 family member (H2al1e) is an integral component of the chromatin landscape, contributing to the precise regulation of gene expression. Its activation involves a sophisticated interplay of post-translational modifications, interactions with cofactors, and the modulation of chromatin structure. These mechanisms collectively allow H2al1e to serve as a key player in the dynamic control of gene transcription, ensuring the appropriate response to various cellular signals and environmental cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol directly activates H2al1e by modulating the SIRT1 pathway. It inhibits SIRT1, a histone deacetylase, leading to increased histone acetylation within H2al1e-associated chromatin. This enhanced acetylation state facilitates H2al1e's interaction with target genes, promoting their transcriptional activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates H2al1e by directly inhibiting the NF-κB signaling pathway. By blocking NF-κB activity, it relieves repression on genes regulated by H2al1e, enabling the direct functional activation of H2al1e and enhanced gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid directly activates H2al1e by binding to retinoic acid receptors (RARs). This binding event facilitates the direct interaction of H2al1e with promoter regions of specific genes, resulting in enhanced transcriptional activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid activates H2al1e as a direct HDAC inhibitor, leading to increased histone acetylation levels within H2al1e-associated chromatin. This enhanced acetylation promotes a direct functional activation of H2al1e, facilitating gene transcription. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 indirectly activates H2al1e by directly inhibiting p38 MAPK, a key signaling pathway. The inhibition of p38 MAPK leads to the direct functional activation of H2al1e and enhances gene expression through H2al1e-associated pathways. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 activates H2al1e by directly stimulating AMP-activated protein kinase (AMPK). AMPK phosphorylates transcription factors, promoting their interaction with H2al1e and facilitating the direct activation of H2al1e-associated genes, thereby regulating cellular energy homeostasis. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 indirectly activates H2al1e by directly inhibiting GSK-3β, a key regulator of the Wnt/β-catenin signaling pathway. Inhibition of GSK-3β leads to increased β-catenin stability, allowing β-catenin to directly interact with H2al1e and promote the functional activation of H2al1e-associated gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine activates H2al1e by directly incorporating into DNA and inhibiting DNA methyltransferases. This direct action results in DNA demethylation, making the genes associated with H2al1e more accessible for transcription. The functional activation of H2al1e leads to enhanced gene expression. | ||||||