OTTMUSG00000016790 Inhibitors
Histone cluster 2 family member, a variant of histone proteins, plays a pivotal role in chromatin structure and gene regulation. The chemical inhibitors listed above, all being histone deacetylase inhibitors, target this protein by modifying its acetylation state, which in turn influences chromatin architecture and function. Trichostatin A, for instance, increases the acetylation of histone proteins, including histone cluster 2 family member, leading to a relaxed chromatin structure. This relaxation disrupts the normal functioning of the protein in maintaining compact chromatin, essential for regulated gene expression. Similarly, Sodium Butyrate, by inhibiting histone deacetylation, elevates acetylation levels of histones, impacting the protein's ability to perform its role in chromatin remodeling and gene expression control.
Continuing with inhibitors like Vorinostat, Panobinostat, and Valproic Acid, these chemicals also act as histone deacetylase inhibitors, leading to an increased acetylation of histone cluster 2 family member. The consequence is a more open chromatin conformation, which is less conducive to the protein's normal role in chromatin organization and gene regulation. Inhibitors such as Romidepsin and Belinostat function similarly, maintaining higher levels of acetylation on histone proteins, thus affecting chromatin structure and the role of histone cluster 2 family member. Entinostat, Tacedinaline, Quisinostat, Mocetinostat, and Givinostat all work by the same mechanism of inhibiting histone deacetylase, leading to changes in the chromatin structure through increased histone acetylation. These changes affect the functionality of histone cluster 2 family member in chromatin remodeling and gene expression control. The consistent theme across these inhibitors is their ability to disrupt the normal compact structure of chromatin, crucial for the functional role of histone cluster 2 family member, thereby inhibiting its ability to effectively participate in chromatin organization and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can increase the acetylation of histone proteins including histone cluster 2 family member. This heightened acetylation disrupts the compact chromatin structure, impairing the normal function of the protein in chromatin compaction and gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, elevating acetylation levels of histones including histone cluster 2 family member. This modification can lead to a more open chromatin structure, thereby inhibiting the protein's role in chromatin remodeling and gene expression control. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that prevents deacetylation of histones, affecting histone cluster 2 family member. Increased acetylation can disrupt the compact chromatin structure, inhibiting the protein's role in chromatin organization and gene regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat, a broad-spectrum histone deacetylase inhibitor, increases acetylation of histones including histone cluster 2 family member. This change can affect chromatin structure, impacting the protein's function in maintaining chromatin integrity and regulating gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, a mood stabilizer and histone deacetylase inhibitor, leads to increased acetylation of histones, affecting histone cluster 2 family member. This elevated acetylation changes chromatin structure, inhibiting the protein's role in chromatin organization and gene expression control. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin, a histone deacetylase inhibitor, increases acetylation levels of histone proteins, affecting histone cluster 2 family member. This can impair the protein's functionality in terms of chromatin compaction and gene regulation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat functions as a histone deacetylase inhibitor, maintaining higher acetylation levels on histone proteins, including histone cluster 2 family member, thereby affecting the chromatin structure and the protein's role in chromatin remodeling and gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275, a histone deacetylase inhibitor, leads to increased acetylation of histone proteins, impacting histone cluster 2 family member. This results in a more open chromatin structure, inhibiting the protein's functionality in chromatin organization and gene regulation. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $99.00 $536.00 | 1 | |
CI 994 is a histone deacetylase inhibitor that increases the acetylation levels of histones, affecting the structural organization of chromatin and thereby inhibiting the role of histone cluster 2 family member in chromatin compaction and gene expression control. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585 enhances acetylation of histone proteins as a histone deacetylase inhibitor, including histone cluster 2 family member. This alteration inhibits the protein's functionality in chromatin organization and gene expression regulation. | ||||||