OTTMUSG00000016788 Activators
Histone cluster 2 family member (H2al1g) plays a critical role in the regulation of chromatin structure and epigenetic control, influencing gene expression patterns. The activation of H2al1g is intricately linked to various chemical compounds that modulate its function, ultimately leading to the transcriptional activation of target genes. H2al1g primarily undergoes activation through the modulation of chromatin structure via histone acetylation. Compounds such as Trichostatin A, Sodium Butyrate, and Valproic Acid act as histone deacetylase (HDAC) inhibitors, resulting in increased histone acetylation levels. This epigenetic modification promotes an open chromatin configuration at the H2al1g gene locus, facilitating the binding of transcription factors to the promoter region and subsequent gene transcription. Additionally, H2al1g can be indirectly activated through various signaling pathways. Compounds like Curcumin and Resveratrol activate H2al1g by influencing the NF-κB and SIRT1 pathways, respectively. These chemicals initiate downstream signaling cascades that enhance the transcription of H2al1g. Similarly, Epigallocatechin Gallate (EGCG) and 5-Aza-2'-deoxycytidine activate H2al1g by modulating DNA methylation levels at the gene promoter, resulting in an active chromatin state that supports gene expression.
Furthermore, chemicals like SB203580 and PD98059 activate H2al1g indirectly by impacting the p38 MAPK and MEK/ERK pathways, respectively. Suppression of these pathways leads to altered gene expression patterns, including increased transcription of H2al1g, mediated by downstream signaling events. Sodium Arsenite activates H2al1g through oxidative stress-induced signaling, and Betulinic Acid promotes H2al1g activation via NF-κB signaling modulation. GW5074 activates H2al1g indirectly by inhibiting the Raf/MEK/ERK pathway, resulting in altered gene expression patterns. In summary, the activation of H2al1g is a multifaceted process involving histone acetylation, DNA methylation, and the modulation of various signaling pathways. Understanding these mechanisms is crucial for deciphering the intricate regulatory network of H2al1g in the context of epigenetic regulation and gene expression.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A functions as an inhibitor of histone deacetylases (HDACs), leading to histone hyperacetylation. This alteration enhances chromatin accessibility, promoting the transcriptional activation of the H2al1g gene by allowing greater access to the gene promoter regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor, similar to Trichostatin A. It increases histone acetylation levels, promoting a more open chromatin structure that facilitates gene activation of H2al1g by enabling the binding of transcription factors to the promoter region. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid serves as an HDAC inhibitor, resulting in increased histone acetylation. This modification positively influences the chromatin structure at the H2al1g gene locus, leading to enhanced gene expression by promoting an open chromatin configuration that supports transcription factor access to the promoter. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates H2al1g indirectly through the NF-κB pathway. It promotes the transcription of NF-κB-responsive genes, including H2al1g, by facilitating NF-κB binding to its promoter region. This activation is driven by the induction of downstream signaling cascades associated with NF-κB. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates H2al1g by modulating the SIRT1 pathway. It inhibits SIRT1 deacetylase activity, resulting in increased histone acetylation and, subsequently, the promotion of H2al1g gene transcription. The activation is achieved through epigenetic modulation of chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) functions as an activator by inhibiting DNA methyltransferases (DNMTs). By reducing DNA methylation at the promoter region of H2al1g, EGCG facilitates increased gene transcription and protein expression. This activation is mediated through epigenetic modifications of DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a demethylating agent, can activate H2al1g by inhibiting DNA methyltransferases (DNMTs). It leads to DNA demethylation at the gene promoter, creating an active chromatin state that favors gene transcription and protein expression. The activation occurs through epigenetic modification of DNA. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 activates H2al1g indirectly through the p38 MAPK pathway. Activation of p38 MAPK results in downstream signaling events that lead to the transcriptional activation of target genes, including H2al1g. The activation is mediated by phosphorylation cascades within the p38 MAPK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 activates H2al1g indirectly by inhibiting the MEK/ERK pathway. Inhibition of this pathway leads to altered gene expression patterns, including increased transcription of H2al1g via downstream signaling events. The activation is mediated through the suppression of the MEK/ERK signaling cascade. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite activates H2al1g through oxidative stress. It induces the generation of reactive oxygen species (ROS), which can activate redox-sensitive transcription factors. This leads to the upregulation of H2al1g through the activation of redox-responsive pathways. The activation is driven by oxidative stress-induced signaling. | ||||||