OTTMUSG00000016784 Activators
Histone cluster 2 family member (H2al1h) is a critical protein involved in chromatin remodeling and epigenetic regulation, contributing to the modulation of gene expression. The activation of H2al1h is intricately linked to various chemical compounds that can modulate its function, ultimately influencing gene transcription. H2al1h's primary mechanism of activation revolves around the modulation of chromatin structure through histone acetylation. Compounds such as Trichostatin A, Sodium Butyrate, and Valproic Acid act as histone deacetylase (HDAC) inhibitors, leading to increased histone acetylation levels. This epigenetic modification promotes a more accessible chromatin structure, facilitating the binding of transcription factors and, consequently, the transcriptional activation of the H2al1h gene.
Furthermore, indirect activation of H2al1h can be achieved through chemicals like Curcumin and Resveratrol, which target specific signaling pathways. Curcumin, for instance, activates H2al1h through the NF-κB pathway, enhancing NF-κB-responsive gene transcription, including H2al1h, through the activation of downstream signaling cascades associated with NF-κB. Similarly, Resveratrol modulates the SIRT1 pathway by inhibiting SIRT1 deacetylase activity, resulting in increased histone acetylation and, consequently, H2al1h gene transcription. Epigenetic regulation of H2al1h also occurs through DNA methylation inhibitors like Epigallocatechin Gallate and 5-Aza-2'-deoxycytidine. These compounds demethylate DNA at the gene promoter region, establishing an active chromatin state that favors gene transcription and protein expression. In addition to epigenetic modifications, indirect activation through signaling pathways is observed with chemicals like SB203580 and PD98059, which impact the p38 MAPK and MEK/ERK pathways, respectively. Suppression of these pathways leads to altered gene expression patterns, including increased transcription of H2al1h, mediated by downstream signaling events. In summary, H2al1h's activation involves a complex interplay of histone modifications, DNA methylation, and specific signaling pathways. Understanding these mechanisms is essential for unraveling the regulatory network of H2al1h in the context of epigenetic regulation and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A functions as an inhibitor of histone deacetylases (HDACs), leading to histone hyperacetylation. This alteration enhances chromatin accessibility, promoting the transcriptional activation of the H2al1h gene by allowing greater access to the gene promoter regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor, similar to Trichostatin A. It increases histone acetylation levels, promoting a more open chromatin structure that facilitates gene activation of H2al1h by enabling the binding of transcription factors to the promoter region. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid serves as an HDAC inhibitor, resulting in increased histone acetylation. This modification positively influences the chromatin structure at the H2al1h gene locus, leading to enhanced gene expression by promoting an open chromatin configuration that supports transcription factor access to the promoter. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates H2al1h indirectly through the NF-κB pathway. It promotes the transcription of NF-κB-responsive genes, including H2al1h, by facilitating NF-κB binding to its promoter region. This activation is driven by the induction of downstream signaling cascades associated with NF-κB. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates H2al1h by modulating the SIRT1 pathway. It inhibits SIRT1 deacetylase activity, resulting in increased histone acetylation and, subsequently, the promotion of H2al1h gene transcription. The activation is achieved through epigenetic modulation of chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) functions as an activator by inhibiting DNA methyltransferases (DNMTs). By reducing DNA methylation at the promoter region of H2al1h, EGCG facilitates increased gene transcription and protein expression. This activation is mediated through epigenetic modifications of DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine, a demethylating agent, can activate H2al1h by inhibiting DNA methyltransferases (DNMTs). It leads to DNA demethylation at the gene promoter, creating an active chromatin state that favors gene transcription and protein expression. The activation occurs through epigenetic modification of DNA. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 activates H2al1h indirectly through the p38 MAPK pathway. Activation of p38 MAPK results in downstream signaling events that lead to the transcriptional activation of target genes, including H2al1h. The activation is mediated by phosphorylation cascades within the p38 MAPK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 activates H2al1h indirectly by inhibiting the MEK/ERK pathway. Inhibition of this pathway leads to altered gene expression patterns, including increased transcription of H2al1h through downstream signaling events. The activation is mediated by the suppression of the MEK/ERK signaling cascade. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite activates H2al1h through oxidative stress. It induces the generation of reactive oxygen species (ROS), which can activate redox-sensitive transcription factors. This leads to the upregulation of H2al1h through the activation of redox-responsive pathways. The activation is driven by oxidative stress-induced signaling. | ||||||