OTTMUSG00000016784 Inhibitors
The inhibition of the protein histone cluster 2 family member (H2al1h) is achieved through the utilization of various chemical inhibitors, each with its unique mechanism of action. These inhibitors, such as Vorinostat and Trichostatin A, function as histone deacetylase inhibitors (HDAC inhibitors) and play a pivotal role in directly inhibiting H2al1h's functionality. They achieve this by targeting histone deacetylases, enzymes responsible for removing acetyl groups from histones, including those associated with H2al1h. Consequently, the inhibition of HDACs by these chemicals results in the preservation of acetyl groups on histones, leading to alterations in chromatin structure. This, in turn, affects the accessibility of DNA for transcription factors, ultimately leading to the inhibition of H2al1h's role in gene expression.
Additionally, GSK-J4 is another chemical inhibitor that indirectly influences H2al1h by targeting histone demethylase JMJD3. By inhibiting JMJD3, GSK-J4 can modulate the histone methylation status associated with H2al1h. This epigenetic modification can lead to changes in the transcriptional regulation of H2al1h and impact its functional activity. Similarly, C646 serves as a selective inhibitor of the histone acetyltransferase (HAT) p300/CBP, which directly inhibits HAT activity. This inhibition of HAT activity results in reduced histone acetylation, including that of H2al1h, thereby impairing its ability to participate in chromatin remodeling and gene expression. In summary, the inhibition of the protein histone cluster 2 family member (H2al1h) is achieved through a range of chemical inhibitors that directly or indirectly affect its functionality. HDAC inhibitors like Vorinostat and Trichostatin A, as well as other inhibitors like GSK-J4 and C646, target specific molecular pathways associated with H2al1h, leading to alterations in histone modifications and gene expression, ultimately inhibiting the protein's function in chromatin regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor (HDAC inhibitor). It directly inhibits the deacetylation of histones, including H2al1h, leading to altered chromatin structure and gene expression changes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is another HDAC inhibitor that directly targets histone deacetylases. It prevents the removal of acetyl groups from histones, including H2al1h, resulting in epigenetic modifications that inhibit its function. | ||||||
GSK J1 | 1373422-53-7 | sc-391113 sc-391113A | 10 mg 50 mg | $189.00 $797.00 | ||
GSK J1 is a specific inhibitor of histone demethylase JMJD3. By inhibiting JMJD3, it indirectly affects H2al1h's histone methylation status, leading to transcriptional regulation and functional inhibition of the protein. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective inhibitor of the histone acetyltransferase (HAT) p300/CBP. It directly inhibits HAT activity, impacting histone acetylation, including H2al1h's acetylation status, resulting in functional inhibition. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase (DNMT) inhibitor. It indirectly influences H2al1h by preventing DNA methylation, which can affect the epigenetic regulation of gene expression, including the inhibition of H2al1h function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a bromodomain and extra-terminal domain (BET) inhibitor. It directly targets the bromodomain proteins that bind to acetylated histones, including H2al1h, leading to transcriptional repression and functional inhibition. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $92.00 $120.00 | ||
Nutlin-3 is an inhibitor of the p53-MDM2 interaction. While not directly targeting H2al1h, it indirectly affects the protein by influencing the p53 pathway, which can lead to altered gene expression and functional inhibition. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB 216763 is a selective inhibitor of GSK-3β (glycogen synthase kinase 3 beta). It indirectly affects H2al1h by modulating the Wnt signaling pathway, which can influence chromatin remodeling and gene expression, leading to inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK (c-Jun N-terminal kinase) inhibitor. It indirectly affects H2al1h by inhibiting JNK signaling, which can lead to altered phosphorylation patterns of histones and functional inhibition of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K (phosphoinositide 3-kinase) inhibitor. It indirectly influences H2al1h by blocking the PI3K/AKT signaling pathway, which plays a role in histone modifications and gene expression, leading to functional inhibition. | ||||||