OTTMUSG00000016611 Activators
KRAB box and zinc finger, C2H2 type domain containing protein is a versatile transcriptional regulator involved in gene expression control. It possesses zinc finger domains that enable specific DNA binding and transcriptional modulation. This protein plays a crucial role in the epigenetic regulation of target genes, acting as a transcriptional repressor or activator depending on its interactions with other molecules. Activation of KRAB box and zinc finger protein primarily occurs through epigenetic mechanisms. The chemicals listed in the table above serve as activators by inhibiting histone deacetylases, promoting histone hyperacetylation, and subsequently leading to the epigenetic activation of this protein. Additionally, some chemicals indirectly activate this protein by modulating various signaling pathways, such as retinoic acid receptor signaling or SIRT1 pathway, which enhance the expression and functional activation of KRAB box and zinc finger, C2H2 type domain containing protein.
In conclusion, the functional activation of KRAB box and zinc finger, C2H2 type domain containing protein is essential for its role in gene regulation and transcriptional control. The chemicals mentioned in the table provide valuable tools for researchers to study and manipulate the functions of this protein, particularly in the context of epigenetic modifications and gene expression regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate activates the protein by functioning as a histone deacetylase inhibitor. This leads to histone hyperacetylation, resulting in epigenetic activation of KRAB box and zinc finger protein. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid indirectly activates the target protein by modulating the retinoic acid receptor (RAR) signaling pathway, enhancing the expression and functional activation of KRAB box and zinc finger protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that activates the protein by promoting histone hyperacetylation, leading to epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid activates the protein by inhibiting histone deacetylases (HDACs), resulting in increased histone acetylation and epigenetic activation of KRAB box and zinc finger protein. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin indirectly activates the target protein by modulating various signaling pathways, including NF-κB and AP-1, leading to increased expression and functional activation of KRAB box and zinc finger protein. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine activates the protein by incorporating into DNA and inhibiting DNA methyltransferases, resulting in DNA demethylation and subsequent expression and functional activation of KRAB box and zinc finger protein. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide activates the protein by functioning as a histone deacetylase inhibitor. It promotes histone hyperacetylation, leading to epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
Sodium Phenylbutyrate activates the protein by inhibiting histone deacetylases (HDACs), resulting in increased histone acetylation and epigenetic activation of KRAB box and zinc finger protein. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat (SAHA) is a histone deacetylase inhibitor that activates the protein by promoting histone hyperacetylation, leading to epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Aza-2'-deoxycytidine (Decitabine) activates the target protein by incorporating into DNA and inhibiting DNA methyltransferases, leading to DNA demethylation and functional activation of KRAB box and zinc finger protein. | ||||||