OTTMUSG00000010136 Inhibitors
Chemical inhibitors of the protein targeted by OTTMUSG00000010136 operate through various molecular mechanisms to disrupt the protein's function. Wortmannin and LY294002 specifically inhibit phosphoinositide 3-kinases (PI3K), a class of enzymes integral to numerous cellular functions, including those related to the protein's activity. By blocking PI3K, these inhibitors can impair the signaling pathways necessary for the correct localization and action of the protein. Similarly, U0126 and PD98059 target the mitogen-activated protein kinase kinase (MEK), leading to the suppression of the MAPK/ERK pathway. This pathway is crucial for a range of cellular activities, and its inhibition can lead to diminished functionality of the protein. Another inhibitor, SP600125, obstructs the activity of c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathways, while SB203580 specifically inhibits p38 MAPK, which is implicated in the control of inflammatory responses and apoptosis, both of which can be linked to the protein's role within the cell.
Furthermore, Go6983 suppresses protein kinase C (PKC), which is involved in the phosphorylation of proteins, a post-translational modification essential for the activation of various signaling cascades that can affect the protein's function. Y-27632 interferes with the Rho-associated protein kinase (ROCK), which is known to regulate actin cytoskeleton dynamics, a structural framework that could be pivotal for the protein's activity. ML7 inhibits myosin light chain kinase (MLCK), which plays a role in actin-myosin contraction, a process potentially crucial for the proper functioning of the protein. KN-93 obstructs calcium/calmodulin-dependent protein kinase II (CaMKII), thereby potentially disrupting cellular processes that involve the protein. BAPTA-AM, a calcium chelator, can lower intracellular calcium levels, which are important for the regulation of various enzymes and signaling pathways. Lastly, Thapsigargin serves as an inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), disrupting calcium homeostasis, which can affect processes involving the protein, leading to its functional inhibition. Each of these inhibitors, by targeting distinct molecular pathways and processes, can contribute to the inhibition of the protein's function within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those related to membrane trafficking and protein localization. Inhibition of PI3K can disrupt the membrane dynamics required for the proper function of OTTMUSG00000010136. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that impedes the PI3K/Akt pathway. This pathway is critical for many cellular processes, including those that may be required for the function of OTTMUSG00000010136. By inhibiting PI3K, LY294002 can disrupt the localization and function of OTTMUSG00000010136. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which blocks the MAPK/ERK pathway. As this pathway can regulate cellular processes that involve OTTMUSG00000010136, U0126 can inhibit the activity of OTTMUSG00000010136 by disrupting these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, similar to U0126, it prevents the activation of the MAPK/ERK pathway. By doing so, PD98059 can inhibit signaling events that are necessary for the functional activity of OTTMUSG00000010136. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathways. JNK activity can influence the function of OTTMUSG00000010136, and its inhibition by SP600125 can lead to the functional inhibition of OTTMUSG00000010136. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. The p38 MAPK signaling pathway plays a role in inflammatory responses and apoptosis. Inhibition of p38 MAPK by SB203580 can alter cellular responses that are essential for OTTMUSG00000010136 function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a protein kinase C (PKC) inhibitor. PKC enzymes are involved in controlling the function of other proteins through phosphorylation. By inhibiting PKC, Go6983 can prevent the phosphorylation and subsequent activation of pathways necessary for OTTMUSG00000010136 function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase (ROCK), which can regulate actin cytoskeleton dynamics. Since the actin cytoskeleton can be crucial for the function of OTTMUSG00000010136, its inhibition by Y-27632 can lead to the functional inhibition of OTTMUSG00000010136. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the regulation of actin-myosin contraction within the cell. Inhibition of MLCK by ML7 can affect cellular processes that require actin dynamics, thus potentially inhibiting the function of OTTMUSG00000010136. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). The activity of CaMKII is important for many cellular processes, including those that may involve OTTMUSG00000010136. By inhibiting CaMKII, KN-93 can inhibit these processes and thus the function of OTTMUSG00000010136. | ||||||