Ost1 Activators
Ost1 Activators are chemicals that either directly or indirectly enhance the functional activity of Ost1. These chemicals exert their effects by influencing intracellular levels of calcium or cyclic nucleotides (cAMP and cGMP), which are crucial second messengers in cellular signaling. For instance, A23187, Thapsigargin, Ionomycin, 2-APB, and Ryanodine can manipulate cytoplasmic calcium levels, thereby leading to the activation of Ost1, which contains EF-hand calcium-binding motifs. When these motifs bind calcium, the functional activity of Ost1 is enhanced.
Alternatively, Forskolin, Isoproterenol, IBMX, and Rolipram increase cAMP levels in cells, and YC-1, Sildenafil, and BAY 41-2272 increase cGMP levels. cAMP and cGMP are intracellular second messengers that can activate protein kinases A (PKA) and G (PKG), respectively. PKA and PKG can phosphorylate Ost1, enhancing its functional activity. These chemicals, therefore, provide the means to specifically manipulate the functional activity of Ost1 via distinct pathways, enabling detailed studies of Ost1's role in cellular signaling. Each class of Ost1 activators-those that increase intracellular calcium, cAMP, or cGGMP-offers distinct mechanisms to activate Ost1, providing a diverse toolkit for researchers to probe the functional roles of Ost1 in cellular signaling events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases cytoplasmic calcium levels. An increase in cytoplasmic calcium can lead to the activation of Ost1 by binding to its EF-hand calcium-binding motifs. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump, leading to a rise in cytoplasmic calcium levels which can activate Ost1 by binding to its EF-hand calcium-binding motifs. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases cytoplasmic calcium levels. An increase in cytoplasmic calcium can lead to the activation of Ost1 by binding to its EF-hand calcium-binding motifs. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is an inositol trisphosphate (IP3) receptor antagonist that can lead to an increase in cytoplasmic calcium levels, leading to the activation of Ost1 by binding to its EF-hand calcium-binding motifs. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine binds to ryanodine receptors and modulates calcium release from the sarcoplasmic/endoplasmic reticulum, leading to increased cytoplasmic calcium levels, which can activate Ost1 by binding to its EF-hand calcium-binding motifs. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels, which can activate protein kinase A (PKA). PKA can then phosphorylate Ost1, enhancing its functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, activating PKA, which can then phosphorylate Ost1, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, increasing cAMP levels, which can activate PKA. PKA can then phosphorylate Ost1, enhancing its functional activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a specific phosphodiesterase-4 inhibitor, increasing cAMP levels, activating PKA, which can then phosphorylate Ost1, enhancing its functional activity. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $33.00 $124.00 $218.00 $947.00 | 9 | |
YC-1 is a soluble guanylyl cyclase (sGC) activator, leading to an increase in cGMP levels, which can activate protein kinase G (PKG). PKG can then phosphorylate Ost1, enhancing its functional activity. | ||||||