OS4 Activators
OS4, known for its role in lipid trafficking and signaling, primarily functions in phosphatidylinositol 4-phosphate (PI4P)/diacylglycerol (DAG) counter-transport at the Golgi. The activity of this protein can be enhanced by chemicals that increase DAG concentration, such as 1-Oleoyl-2-acetyl-sn-glycerol (OAG) and a diacylglycerol kinase inhibitor, R59022. Also, Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), can enhance OS4's function through its effects on DAG levels. On the other hand, PIK-93, a PI4KIIIβ inhibitor, can indirectly activate OS4 by reducing PI4P levels, thus influencing the counter-transport process.
OS4's activity in vesicular transport can be enhanced by Phenylarsine oxide (PAO), which disrupts vesicular traffic. Lipid homeostasis agents like Progesterone, Cerulenin, and U18666A can augment OS4's lipid transport function by altering lipid composition and intracellular cholesterol transport. Further, the protein's localization to the ER-Golgi interface allows it to be activated by chemicals that induce ER stress, such as Thapsigargin. Filipin III, a cholesterol-binding compound, can enhance OS4's role in cholesterol homeostasis, while Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, can affect OS4's activity by influencing phosphoinositide metabolism.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
OAG is a synthetic diacylglycerol (DAG) analog that increases the DAG concentration. Since OS4 is involved in the phosphatidylinositol 4-phosphate (PI4P)/DAG counter-transport at the Golgi, OAG can enhance the activity of OS4 by providing more substrate for transport. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) that can alter the DAG levels in cells. Altered DAG concentration can enhance the OS4 activity due to the protein's role in DAG homeostasis. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone is a steroid hormone that influences lipid homeostasis. By altering lipid composition, progesterone can enhance OS4's activity in lipid transport. | ||||||
R 59-022 | 93076-89-2 | sc-203227 | 5 mg | $122.00 | 1 | |
R59022 inhibits diacylglycerol kinase, increasing DAG levels in cells, which can enhance OS4 activity related to DAG homeostasis. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is a PI4KIIIβ inhibitor. By inhibiting PI4KIIIβ, PIK-93 reduces PI4P levels, which can enhance OS4 activity, given its role in PI4P-DAG counter-transport. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
PAO disrupts vesicular traffic. Given that OS4 has a role in vesicle transport, alterations in this pathway can activate OS4. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Cerulenin inhibits fatty acid synthesis, affecting lipid homeostasis. Changes in lipid homeostasis can enhance OS4 activity in lipid transport. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A disrupts intracellular cholesterol transport. As OS4 may be involved in cholesterol homeostasis, this can enhance its activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER stress. Given that OS4 is localized to the ER-Golgi interface, alterations in ER function can enhance its activation. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin III binds to cholesterol, affecting its distribution. Since OS4 is involved in cholesterol homeostasis, this can enhance its activity. | ||||||