OS4 Antibody (2230C1a): sc-81347

OS4 Antibody (2230C1a) is a mouse monoclonal IgG2b antibody that detects OS4 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-OS4 antibody (2230C1a) is available as a non-conjugated format. OS4 protein, also known as CTDSP2 (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2) or SCP2, is a 271 amino acid nuclear protein that plays a significant role in the regulation of androgen-dependent transcription, particularly by silencing neuronal genes on a global scale. OS4 is expressed ubiquitously, with notably high levels found in the pancreas, highlighting its importance in various biological processes. OS4 contains a unique FCP1 homology domain and functions as a Smad2/3 linker phosphatase, enhancing Smad2/3 signaling, which is critical in the Smad pathway associated with cellular responses to transforming growth factor-beta (TGF-β). OS4′s interaction with Smad2/3 is essential for the final signaling events in this pathway, making OS4 a key player in the metastasis of certain cancers. Notably, overexpression of OS4 has been linked to the development of primary sarcomas and brain tumors, underscoring its potential as a biomarker for cancer progression and a target for therapeutic intervention.

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OS4 Antibody (2230C1a) References:

1. Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis.  |  Zohn, IE. and Brivanlou, AH. 2001. Dev Biol. 239: 118-31. PMID: 11784023
2. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription.  |  Thompson, J., et al. 2006. EMBO J. 25: 2757-67. PMID: 16724108
3. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.  |  Knockaert, M., et al. 2006. Proc Natl Acad Sci U S A. 103: 11940-5. PMID: 16882717
4. Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling.  |  Wrighton, KH., et al. 2006. J Biol Chem. 281: 38365-75. PMID: 17035229
5. Functional characterization of small CTD phosphatases.  |  Yeo, M. and Lin, PS. 2007. Methods Mol Biol. 365: 335-46. PMID: 17200573
6. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas.  |  Su, YA., et al. 1997. Oncogene. 15: 1289-94. PMID: 9315096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OS4 Antibody (2230C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-OS4 Antibody (2230C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OS4 Antibody (2230C1a) Specifications

Alternate Product Name: OS4

Product Clone Name: 2230C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: OS4

Epitope Species: human

Product Reactivity/Detection: OS4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for OS4 Antibody (2230C1a): N/A