OR8B4 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor could lead to hyperacetylation of histones near the OR8B4 gene, resulting in a relaxed chromatin structure and potentially facilitating the downregulation of OR8B4 by interfering with the recruitment of transcription machinery. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a nucleoside analog, 5-Azacytidine can incorporate into DNA and RNA, causing demethylation of DNA upon cell division. This demethylation could unlock the silenced OR8B4 gene, allowing for its reduced expression if hypermethylation was initially preventing gene transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
This DNA methyltransferase inhibitor could specifically target the methylation status of the OR8B4 gene, leading to the decrease in the gene's expression by preventing the silencing methylation marks from being added to the gene's promoter. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Known to intercalate into DNA, Actinomycin D could directly inhibit the transcription of the OR8B4 gene by blocking the advancement of RNA polymerase along the DNA, resulting in a decrease in OR8B4 mRNA levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
This potent inhibitor of RNA polymerase II could selectively reduce OR8B4 transcription by preventing the elongation phase of mRNA synthesis, leading to a significant decrease in OR8B4 protein production. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
As a selective estrogen receptor degrader, ICI 182,780 (Fulvestrant) might lead to the degradation of estrogen receptors that, if involved in the upregulation of OR8B4, would result in decreased transcriptional activity of the OR8B4 gene. | ||||||
Vinclozolin | 50471-44-8 | sc-251425 | 250 mg | $23.00 | 1 | |
This fungicide with antiandrogenic properties could lead to the downregulation of OR8B4 expression by antagonizing androgen receptors that may play a role in the normal expression of the OR8B4 gene. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
This compound, also known for its potent inhibition of steroid synthesis, could indirectly lead to decreased OR8B4 expression by altering steroid hormone levels that might be necessary for the gene's expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
By binding to GC-rich sequences in DNA, Mithramycin A could inhibit the binding of transcription factors to the OR8B4 promoter, leading to a significant reduction in the gene's expression levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine's ability to increase the pH of intracellular vesicles might disrupt the processing and trafficking of the G-protein-coupled receptors like OR8B4, leading to its decreased presence on the cell surface and reduced functional expression. | ||||||