Date published: 2025-11-25

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OR52R1 Inhibitors

OR52R1 inhibitors refer to a specific class of compounds that target the OR52R1 protein, which is a member of the olfactory receptor family. These receptors are part of the G-protein-coupled receptor (GPCR) superfamily, which is involved in a wide range of physiological processes. Olfactory receptors, including OR52R1, are typically associated with the detection of odor molecules, but they are also expressed in various non-olfactory tissues. The role of OR52R1 outside the olfactory system is still under investigation, and it is believed to have functions that extend beyond smell perception. The inhibitors of OR52R1 are designed to interact with the receptor in such a way that they block or alter its activity, leading to potential changes in the biological processes in which OR52R1 is involved. Chemically, OR52R1 inhibitors can vary in their structure and mechanism of action. These inhibitors might bind to the receptor's active site, preventing the binding of natural ligands, or they could induce conformational changes in the receptor that render it inactive. The specificity and potency of these inhibitors depend on their molecular design, which is often guided by the structural characteristics of the OR52R1 receptor. Studies on OR52R1 inhibitors focus on understanding the receptor's signaling pathways, the interactions between the receptor and its inhibitors, and the resulting cellular responses. These studies are crucial for elucidating the functional roles of OR52R1 in various biological contexts. Research in this area often involves a combination of computational modeling, biochemical assays, and structural biology techniques to identify and optimize OR52R1 inhibitors that are effective in modulating the receptor's activity.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This chemical could induce hypomethylation of the OR52R1 gene promoter, resulting in the attenuation of its transcriptional activity by altering the chromatin architecture.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

By inhibiting histone deacetylase, Trichostatin A may lead to the hyperacetylation of histones, which could repress the transcription initiation complex assembly at the OR52R1 locus.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

Vorinostat could lead to the hyperacetylation of histone proteins associated with the OR52R1 gene, causing a downregulation of its transcriptional output.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$88.00
$208.00
24
(2)

The selective inhibition of Class I HDACs by MS-275 (Entinostat) might result in altered acetylation status of histones at the OR52R1 site, culminating in a diminished gene expression profile.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

Methotrexate could lead to a depletion of nucleotide precursors, which may result in a reduced transcription rate of the OR52R1 gene due to a scarcity of essential transcription substrates.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

By inhibiting DNA methyltransferases, Decitabine could cause hypomethylation of the OR52R1 gene′s regulatory regions, potentially leading to decreased gene expression levels.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$52.00
$87.00
7
(1)

Disulfiram could indirectly lead to the repression of OR52R1 through the alteration of metal ion homeostasis, which may interfere with the binding of transcription factors to the OR52R1 promoter.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Sodium Butyrate, through its HDAC inhibitory action, could induce histone hyperacetylation and subsequently repress the initiation of transcription at the OR52R1 gene locus.

Temozolomide

85622-93-1sc-203292
sc-203292A
25 mg
100 mg
$89.00
$250.00
32
(1)

Temozolomide could methylate the OR52R1 gene directly, potentially leading to transcriptional silencing or introduce mutations that could lead to the loss of functional OR52R1 transcript production.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

Alpha-amanitin could inhibit the transcription of OR52R1 by binding to RNA polymerase II, leading to a halt in the elongation phase of mRNA synthesis for this gene.