OR4C13 Activators
OR4C13 can initiate a cascade of intracellular events leading to its activation. Isoproterenol, a non-selective beta-adrenergic agonist, engages with beta-adrenergic receptors, which can result in the activation of adenylate cyclase and a subsequent rise in cyclic AMP levels. This increase in cyclic AMP facilitates the activation of protein kinase A (PKA), which is known to phosphorylate various proteins, including those in the olfactory signaling pathways where OR4C13 is involved. Similarly, Forskolin, by directly stimulating adenylyl cyclase, bypasses receptor interaction and leads to an elevated cyclic AMP concentration that activates PKA, which in turn can act on OR4C13. IBMX, with its phosphodiesterase inhibiting properties, prevents the breakdown of cyclic AMP, thus sustaining PKA activation and influencing the activity of OR4C13.
VU0359595, a selective agonist for GPR3, is capable of increasing cyclic AMP production, which also leads to PKA activation and may influence OR4C13 activity. Epinephrine, through its action on beta-adrenergic receptors, and Terbutaline, a beta2-adrenergic agonist, both lead to increased cyclic AMP and PKA activation, following a similar route as Isoproterenol. Dopamine and Histamine act on their respective Gs-protein coupled receptors, D1-like and H2, to increase cyclic AMP and activate PKA, which can play a role in the activation of OR4C13. Adenosine, interacting with A2A receptors, and PGE2, through EP2 and EP4 receptors, both raise cyclic AMP levels, enabling PKA to phosphorylate and influence proteins in the olfactory signaling pathways, including OR4C13. Lastly, Rolipram and Zaprinast inhibit specific phosphodiesterase enzymes, leading to an accumulation of cyclic AMP and sustained activation of PKA, which may enhance the activity of OR4C13 within olfactory signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that can activate the adrenergic receptors, which may enhance the activity of proteins like OR4C13 by increasing intracellular cyclic AMP levels, leading to activation of protein kinase A (PKA) and subsequent phosphorylation and activation of proteins associated with olfactory signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cyclic AMP levels in the cell. Elevated cyclic AMP activates protein kinase A (PKA), which can phosphorylate and activate proteins involved in the olfactory transduction pathway, including OR4C13. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, enzymes that break down cyclic AMP. By inhibiting these enzymes, IBMX increases cyclic AMP levels, thereby activating PKA which may lead to the phosphorylation and activation of olfactory receptors such as OR4C13. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with beta-adrenergic receptors leading to adenylate cyclase activation, increased cyclic AMP levels, and activation of PKA. PKA can phosphorylate components of the olfactory transduction pathway potentially resulting in the activation of olfactory receptors including OR4C13. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through its action on D1-like receptors which are Gs-protein coupled, can increase cyclic AMP levels in certain cell types, potentially leading to activation of PKA and subsequent activation of proteins in olfactory signal transduction pathways, including OR4C13. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can act on H2 receptors which are positively coupled to adenylyl cyclase via Gs proteins, leading to increased cyclic AMP and activation of PKA. This can result in the activation of the olfactory receptor OR4C13 as part of the olfactory signaling cascade. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with A2A receptors, which are Gs protein-coupled, leading to increased cyclic AMP levels and PKA activation. PKA can phosphorylate and activate proteins within the olfactory signal transduction pathways, including OR4C13. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) can interact with EP2 and EP4 receptors that are coupled with Gs proteins, increasing cyclic AMP levels and activating PKA. PKA may phosphorylate and activate proteins that are part of the olfactory signaling cascade, including OR4C13. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic receptor agonist that leads to the activation of adenylate cyclase, increased cyclic AMP, and PKA activation. PKA can then activate proteins in the olfactory signal transduction pathways, including OR4C13. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cyclic AMP levels in cells. This increase can activate PKA, which may then phosphorylate and activate proteins in the olfactory transduction pathway, including OR4C13. | ||||||