oogenesin 2 Inhibitors
Oog2, also known as oogenesin 2, is a gene found in Mus musculus (house mouse). It is predicted to enable ubiquitin ligase-substrate adaptor activity, suggesting its involvement in protein ubiquitination processes. Furthermore, Oog2 is associated with several biological processes, including negative regulation of apoptosis, negative regulation of transcription, DNA-templated, and positive regulation of cell population proliferation. Additionally, it is predicted to be part of the Cul2-RING ubiquitin ligase complex and primarily active in the cytoplasm. Oog2 shares orthologs with several human genes, including PRAMEF1, PRAMEF10, and PRAMEF11. Given Oog2's predicted functions, we can explore potential inhibitors that may influence its activity indirectly. While specific inhibitors for Oog2 are not currently available, we can consider compounds that target pathways and cellular processes associated with its functions. For example, proteasome inhibitors like MG-132 and Bortezomib may affect Oog2 by modulating the degradation of ubiquitin-tagged substrates, potentially impacting its ubiquitin ligase-substrate adaptor activity. Additionally, inhibitors like Nutlin-3 and Gossypol can indirectly influence Oog2 by modulating apoptosis-related processes.
Furthermore, compounds such as Doxorubicin and Cycloheximide can impact transcription and protein synthesis, potentially affecting Oog2's roles in transcriptional regulation and cell proliferation. Inhibition of PI3K by Wortmannin and p38 MAPK by SB203580 may also indirectly influence Oog2's functions related to cell proliferation. These chemicals provide avenues for further research into Oog2's regulatory mechanisms and applications in the future. In conclusion, Oog2 is a gene with predicted functions related to ubiquitin ligase-substrate adaptor activity, apoptosis regulation, transcriptional control, and cell population proliferation. While specific inhibitors for Oog2 are currently lacking, exploring chemicals that target related pathways and processes provides valuable insights into its potential inhibition. Further research is needed to elucidate the precise role of Oog2 and its susceptibility to inhibition, paving the way for a deeper understanding of its functions in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can indirectly affect Oog2 by inhibiting the degradation of ubiquitin-tagged substrates, potentially influencing the ubiquitin ligase-substrate adaptor activity. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $120.00 $215.00 | 2 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, leading to increased p53 levels. Elevated p53 can influence transcription, including negative regulation, which may impact Oog2's functions. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin hydrochloride is an anthracycline antibiotic that can induce apoptosis in various cell types. If Oog2 negatively regulates apoptosis, Doxorubicin may indirectly affect its function by promoting cell death. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. PI3K/AKT signaling can impact cell proliferation. Inhibition of PI3K by Wortmannin may indirectly influence Oog2's role in cell population proliferation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is an RNA synthesis inhibitor. It can affect transcription, including negative regulation of transcription, which may indirectly influence Oog2's predicted functions in transcriptional regulation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor. It can influence the synthesis of proteins involved in cell proliferation and apoptosis, potentially impacting Oog2's roles in these processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. Similar to MG-132, it can indirectly affect Oog2 by inhibiting the proteasome and altering the degradation of ubiquitin-tagged substrates. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $114.00 $225.00 | 12 | |
Gossypol has been studied for its pro-apoptotic properties. If Oog2 negatively regulates apoptosis, Gossypol may indirectly influence its function by promoting apoptotic processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. p38 MAPK signaling can impact transcription and cell proliferation. Inhibition of p38 MAPK by SB203580 may indirectly influence Oog2's functions in these processes. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is a thymidylate synthase inhibitor used in cancer therapy. It can affect DNA synthesis and potentially influence Oog2's roles in transcription and cell proliferation. | ||||||