oogenesin 2 Activators
Oogenesin 2 is a protein with predicted ubiquitin ligase-substrate adaptor activity, involved in various cellular processes, including the negative regulation of apoptosis, transcription, and the positive regulation of cell population proliferation. It is part of the Cul2-RING ubiquitin ligase complex and is primarily active in the cytoplasm. This protein plays a critical role in regulating intracellular processes and maintaining cellular homeostasis.
The functional activation of Oogenesin 2 can be influenced by several chemicals, each with specific mechanisms. Some chemicals, like 2-Mercaptoethanol and Auranofin, directly interact with the protein, stabilizing its structure and enhancing its ubiquitin ligase-substrate adaptor activity. Others, such as MG-132 and Rapamycin, indirectly affect Oogenesin 2 by modulating cellular pathways involved in protein degradation and cell proliferation, respectively. Furthermore, compounds like N-Acetylcysteine and Resveratrol support Oogenesin 2's role in protecting against oxidative stress and transcriptional regulation by preserving its structural integrity. These chemicals collectively contribute to the functional activation of Oogenesin 2, ensuring its involvement in essential cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
2-Mercaptoethanol activates Oogenesin 2 by participating in redox reactions within the cytoplasm. It promotes disulfide bond formation and structural changes in the protein, leading to its functional activation, enabling its role in ubiquitin ligase-substrate interactions. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine activates Oogenesin 2 indirectly by replenishing intracellular glutathione levels. This antioxidant property safeguards the protein from oxidative damage, ensuring its structural integrity and promoting its role in regulating apoptotic processes. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG activates Oogenesin 2 by binding to Hsp90, a protein chaperone involved in protein folding. This interaction stabilizes Oogenesin 2 and prevents its degradation, allowing for sustained ubiquitin ligase-substrate adaptor activity, influencing cellular processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin indirectly activates Oogenesin 2 by inhibiting the mTOR complex, a central regulator of cell growth. This inhibition leads to reduced cell proliferation, indirectly promoting Oogenesin 2's role in the negative regulation of cell population proliferation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates Oogenesin 2 through its role as a sirtuin activator. By activating SIRT1, it enhances Oogenesin 2 deacetylation, stabilizing the protein and facilitating its function in the negative regulation of transcription, DNA-templated. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin activates Oogenesin 2 by inhibiting thioredoxin reductase, leading to increased oxidative stress in the cytoplasm. This stress triggers Oogenesin 2's protective responses, including its role in negative regulation of apoptotic processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates Oogenesin 2 by influencing the Nrf2-Keap1 pathway. It promotes Nrf2 stabilization, leading to increased expression of antioxidant enzymes. This indirectly supports Oogenesin 2 in its role of negative regulation of apoptotic processes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates Oogenesin 2 by modulating the Wnt/β-catenin pathway. It inhibits GSK-3β, leading to β-catenin stabilization and enhanced transcriptional regulation, indirectly contributing to Oogenesin 2's negative regulation of transcription. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine activates Oogenesin 2 by blocking adenosine receptors in the cytoplasm, increasing cAMP levels. This alteration in intracellular signaling pathways indirectly supports Oogenesin 2 in its role of negative regulation of apoptotic processes. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
Nordihydroguaiaretic Acid (NDGA) activates Oogenesin 2 by acting as an antioxidant and inhibiting lipoxygenases. This reduces oxidative stress in the cytoplasm, indirectly promoting Oogenesin 2's role in the negative regulation of apoptotic processes. | ||||||