OOEP Inhibitors
OOEP inhibitors are chemicals primarily focused on the broader context of oocyte maturation and early embryonic development. These inhibitors, though not directly targeting OOEP, act on signaling pathways and cellular processes that are essential in these developmental stages, where OOEP plays a vital role. Chemicals like Roscovitine, U0126, and LY294002 act by modulating kinases and pathways such as CDKs, MAPK, and PI3K, respectively. These pathways are foundational for follicular development, cell cycle progression in oocytes, and subsequent maturation.
Additionally, the Aurora kinase inhibitor ZM447439 emphasizes the importance of chromosomal alignment and spindle assembly in oocytes. Given the role of OOEP in early embryonic development, modulating these processes can provide an indirect means to influence OOEP's function or expression. Another dimension to consider is protein turnover, with compounds like Bortezomib and MG132 acting as proteasome inhibitors, highlighting the intricate balance of protein synthesis and degradation during oocyte maturation. Autophagy, a vital cellular cleanup mechanism, also plays a role in oocyte development, and its inhibitor, 3-MA, represents this aspect in the group.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Cyclin-dependent kinase (CDK) inhibitor, which can affect cell cycle progression in oocytes, potentially influencing OOEP. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that can modulate pathways essential for follicular development and oocyte maturation, possibly affecting OOEP. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Aurora kinase inhibitor; aurora kinases play roles in chromosomal alignment and spindle assembly in oocytes, which can indirectly influence OOEP. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
FGF receptor inhibitor, affecting pathways related to follicular development and oocyte maturation, potentially affecting OOEP. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor, can affect protein degradation mechanisms which are active during oocyte maturation, possibly impacting OOEP. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Another proteasome inhibitor, influencing protein turnover in oocytes which may indirectly influence OOEP. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Autophagy inhibitor, which can play a role in oocyte maturation by modulating cellular cleanup processes, potentially influencing OOEP. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor which affects pathways essential for follicular development and oocyte maturation, possibly affecting OOEP. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor; the JNK pathway is involved in various cellular processes in oocytes, which may indirectly influence OOEP. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor, can affect oocyte maturation and embryo development processes, potentially influencing OOEP. | ||||||