OOEP Activators
OOEP activators are chemicals that indirectly influence the cellular and molecular pathways associated with oocyte maturation and embryonic development, where OOEP is known to play a critical role. The activation of these pathways can lead to upregulation or increased activity of OOEP, albeit through indirect mechanisms. The potential activators range from hormonal molecules like estrogen, which can regulate gene expression through their nuclear receptors, to compounds like forskolin and retinoic acid, which modulate intracellular signaling cascades and transcription factors that could impact OOEP levels.
The involvement of these chemicals in oocyte-related pathways suggests that the maturation and developmental processes are tightly regulated by intracellular second messengers like cAMP, hormonal signaling, and the energy status within the cell, as indicated by AMPK activation. For instance, cAMP is a crucial messenger in the resumption of meiosis and oocyte maturation, and any chemical such as forskolin or rolipram that raises intracellular cAMP levels could potentially contribute to a conducive environment for OOEP expression. Moreover, signaling molecules like EGF and CNP play significant roles in follicle growth and oocyte maturation, thereby modulating the expression of genes like OOEP that are critical during these stages.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels which can enhance the maturation of oocytes, potentially upregulating OOEP as part of the maturation process. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, through its receptor, can regulate gene expression during oocyte maturation. It may affect OOEP by altering transcriptional programs in oocytes. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen, by binding to its nuclear receptor, can modulate gene expression profiles during oocyte development, which may include the activation of OOEP. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, binds to estrogen receptors and could modulate gene expression patterns, potentially influencing OOEP levels. | ||||||
Zearalenone | 17924-92-4 | sc-204943 sc-204943A | 10 mg 50 mg | $120.00 $369.00 | 6 | |
Zearalenone mimics estrogenic activity and could influence oocyte maturation and related gene expression including OOEP. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK, a cellular energy sensor, which can influence oocyte maturation and possibly the expression of OOEP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, elevating cAMP levels, which may impact oocyte maturation and indirectly OOEP expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can modulate metabolic pathways and has roles in follicle development, potentially influencing OOEP expression. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite can induce cellular stress responses, which may affect signaling pathways and gene expression relevant to oocyte maturation and OOEP. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an endocrine disruptor that can interact with estrogen receptors, potentially affecting oocyte maturation and OOEP expression. | ||||||