Olr1733 Activators
Chemical activators of Olr1733 employ a variety of mechanisms to modulate the protein's activity. Forskolin acts by directly stimulating adenylyl cyclase, which increases the intracellular levels of cAMP. The elevated cAMP then activates protein kinase A (PKA), a kinase that can phosphorylate Olr1733, leading to its activation. Similarly, Dibutyryl-cAMP and 8-Bromo-cAMP, both membrane-permeable cAMP analogs, elevate intracellular cAMP levels, activating PKA, which may then target Olr1733 for phosphorylation. Ionomycin, serving as a calcium ionophore, increases the intracellular concentration of calcium ions, which activates calmodulin-dependent kinases capable of phosphorylating Olr1733. BAY K8644, as an L-type calcium channel agonist, induces calcium influx and thus could also activate calcium-dependent kinases that phosphorylate Olr1733.
In parallel, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), another kinase that can phosphorylate Olr1733. Thapsigargin, by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), raises cytosolic calcium levels, which could activate various calcium-dependent signaling pathways and potentially result in the phosphorylation of Olr1733. Okadaic Acid, targeting protein phosphatases such as PP1 and PP2A, prevents the dephosphorylation of proteins, potentially maintaining Olr1733 in an activated state. Zinc Sulfate, which modulates the activity of various kinases and phosphatases through the manipulation of zinc ion concentrations, may also influence the phosphorylation state of Olr1733. Lastly, Anisomycin activates stress-activated protein kinases like JNK and p38 MAP kinase, which could phosphorylate Olr1733, while Sodium Fluoride inhibits protein phosphatases, potentially leading to the accumulation of phosphorylated Olr1733. Together, these chemicals create an environment conducive to the activation of Olr1733 through direct or indirect influence on kinases and phosphatases that regulate the phosphorylation status of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin functions as a calcium ionophore, elevating intracellular calcium levels. The increase in calcium can activate calmodulin-dependent protein kinases (CaMK), which may phosphorylate and activate Olr1733, provided that Olr1733 is a substrate for CaMK. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn can phosphorylate and activate Olr1733, given that Olr1733 is a known substrate for PKC. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), causing a rise in cytosolic calcium levels. This can activate calcium-dependent proteins and pathways that may lead to the activation of Olr1733, particularly if Olr1733 is regulated by calcium-mediated signaling. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 is an L-type calcium channel agonist that increases calcium influx, potentially activating calcium-dependent kinases that could phosphorylate and activate Olr1733. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases such as JNK and p38 MAP kinase, which could lead to the phosphorylation and activation of Olr1733 if it is within their substrate range. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A; by inhibiting dephosphorylation, it can sustain the phosphorylated (active) state of proteins. Assuming Olr1733 is regulated by phosphorylation, this would maintain its activated state. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate can lead to the activation of several kinases and phosphatases due to intracellular zinc ion fluctuations. If Olr1733 activation is sensitive to zinc ion concentrations or if zinc-dependent kinases target Olr1733, this chemical can contribute to its activation. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
Although primarily a PKA inhibitor, H-89 can cause compensatory cellular effects that activate other kinases. These kinases may phosphorylate and activate Olr1733, assuming the protein's activation is kinase-dependent. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that can activate PKA intracellularly. Once inside the cell, it can enhance the phosphorylation of proteins, potentially including Olr1733, if it is a PKA substrate. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is another cAMP analog that activates PKA. PKA then may phosphorylate and activate Olr1733, provided that Olr1733 is among its substrates. | ||||||