Olfr984 Inhibitors
Olfr984 is a member of the olfactory receptor family, crucial for the human olfactory system's ability to detect and distinguish various odorant molecules. Located in the nasal epithelium, Olfr984 functions as a sensory receptor responsible for initiating a complex cascade of events that lead to the perception of odors. The primary function of Olfr984 lies in its capability to recognize and bind to specific odorant molecules. When an odorant molecule interacts with Olfr984 in the nasal cavity, it attaches to the receptor's binding site, initiating a signaling cascade. This cascade results in the generation of cyclic adenosine monophosphate (cAMP), which activates downstream signaling pathways. These pathways transmit electrical signals to the brain, where the perception and differentiation of odors occur. Olfr984 serves as a fundamental link between environmental chemical cues and our conscious experience of odor perception.
Inhibition of Olfr984 can be achieved through both direct and indirect mechanisms. Direct inhibition involves interference with Olfr984's function at the receptor level, where specific chemical compounds directly target the receptor's active sites or transmembrane domains, effectively suppressing its ability to initiate olfactory signal transduction. Indirect inhibition operates by modulating intracellular signaling pathways closely associated with Olfr984's function, leading to altered receptor expression or function. These combined direct and indirect inhibition strategies provide valuable insights into the intricate processes of olfactory signal processing and sensory perception. The study of the precise mechanisms by which Olfr984 can be inhibited contributes to our broader understanding of olfaction and its regulation, offering insights into the fascinating world of odor perception in human sensory experience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid acts as an indirect inhibitor of Olfr984 by influencing the retinoic acid signaling pathway. It modulates gene expression within olfactory neurons, leading to the down-regulation of Olfr984 and its inhibition. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $25.00 $75.00 $150.00 | 32 | |
Daidzein is a direct inhibitor of Olfr984. It binds to Olfr984's active sites, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr984. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits Olfr984 indirectly through the PI3K/Akt pathway. It inhibits PI3K activity, resulting in downstream effects that down-regulate Olfr984 expression and function, ultimately impeding olfactory signal transduction. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol is a direct inhibitor of Olfr984. It binds to Olfr984's transmembrane domain, inhibiting odorant binding and suppressing olfactory signal transduction, effectively impeding the receptor's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 influences Olfr984 indirectly through the MAPK/ERK pathway. It inhibits ERK activation, leading to downstream effects that down-regulate Olfr984 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol acts as an indirect inhibitor of Olfr984 by modulating the sirtuin signaling pathway. It influences the expression of Olfr984 and other genes involved in olfactory signal transduction, leading to its suppression. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is a direct inhibitor of Olfr984. It binds to Olfr984's active sites, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr984. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 influences Olfr984 indirectly through the PI3K/Akt pathway. It inhibits PI3K activity, leading to downstream effects that down-regulate Olfr984 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine inhibits Olfr984 indirectly by interfering with the calcium signaling pathway. It disrupts calcium-mediated processes, leading to the down-regulation of Olfr984 expression and inhibition of olfactory signaling. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is a direct inhibitor of Olfr984. It binds to Olfr984's transmembrane domain, inhibiting odorant binding and suppressing olfactory signal transduction, effectively impeding the receptor's function. | ||||||