Olfr984 Activators
Olfr984 is an olfactory receptor, part of the extensive G-protein-coupled receptor (GPCR) family. These receptors are pivotal in detecting and interpreting a wide array of chemical signals, particularly in the context of olfaction. The specific function of Olfr984, like many olfactory receptors, involves the recognition and binding of odorant molecules. Upon binding of an appropriate ligand, Olfr984 undergoes a conformational change, which is a fundamental aspect of its activation mechanism. This change is crucial for the initiation of downstream intracellular signaling cascades.
The activation of Olfr984, as with other GPCRs, typically involves the coupling of the receptor with G-proteins following ligand binding. This interaction leads to the activation of adenylate cyclase, an enzyme responsible for the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels is a pivotal step, as it activates protein kinase A (PKA). PKA then phosphorylates various cellular targets, leading to diverse cellular responses. This signaling pathway is not only vital for the immediate response to odorant molecules but also plays a role in the regulation of gene expression and cellular behavior over longer periods. The specificity of ligand-receptor interactions, as demonstrated by Olfr984 and its activators, highlights the precision of olfactory perception. Each odorant molecule binding to a distinct receptor like Olfr984 contributes to the rich tapestry of smells and their associated perceptions and responses. Understanding the activation mechanisms of receptors like Olfr984 not only sheds light on sensory biology but also on broader GPCR signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr984 by binding to its orthosteric site, inducing a conformational change that facilitates G-protein coupling. This leads to the activation of adenylate cyclase, increasing cyclic AMP levels, and triggering PKA activation, thereby functionally activating Olfr984. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal activates Olfr984 through direct interaction with its binding domain, triggering a conformational shift. This shift enables G-protein coupling and adenylate cyclase activation, leading to elevated cyclic AMP levels and subsequent PKA activation, functionally activating Olfr984. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr984 by binding to specific sites on the receptor, causing a structural rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr984. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal activates Olfr984 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels and activating PKA, thereby functionally activating Olfr984. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal activates Olfr984 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr984. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal activates Olfr984 by binding directly to the receptor, inducing a conformational change. This activation stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, an increase in cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr984. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates Olfr984 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr984. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr984 by binding to the receptor's active site, causing a conformational shift. This shift facilitates G-protein coupling and activation, leading to adenylate cyclase stimulation, an increase in cyclic AMP, and activation of PKA, functionally activating Olfr984. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene activates Olfr984 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr984. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
(-)-trans-Caryophyllene activates Olfr984 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr984. | ||||||