Olfr90 Inhibitors
Olfr90, a member of the olfactory receptor family in Mus musculus (house mouse), plays a pivotal role in the sense of smell. These olfactory receptors are part of the G-protein-coupled receptor (GPCR) superfamily and feature a 7-transmembrane domain structure. Olfr90 serves as a molecular sensor, detecting specific odorant molecules in the nasal environment and initiating a complex signaling cascade that ultimately leads to the perception of distinct odors. The inhibition of Olfr90 involves a range of chemical compounds that act directly or indirectly on various components of the olfactory signaling pathway. These inhibitors target key elements such as cyclic AMP (cAMP) levels, calcium signaling, protein kinases, and more. Through their actions, these compounds modulate olfactory receptor function, potentially leading to the down-regulation of Olfr90-mediated signal transduction and affecting the perception of specific odors in house mice.
The intricacies of Olfr90 inhibition highlight the complexity of olfaction, where precise modulation of receptor function and signaling pathways is crucial for the perception of a diverse range of odors in the natural environment. Understanding the mechanisms of Olfr90 inhibition provides valuable insights into the intricate processes underlying the sense of smell in house mice, shedding light on the fascinating world of sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to increased intracellular cAMP levels. This indirectly influences Olfr90 by activating protein kinase A (PKA) and potentially modulating olfactory receptor function and the perception of specific odors. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a calcium chelator that can indirectly inhibit Olfr90 by binding and sequestering intracellular calcium ions. This action disrupts calcium-dependent signaling pathways, potentially affecting olfactory receptor function and the perception of specific odors. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB203580 inhibits p38 mitogen-activated protein kinase (MAPK), indirectly impacting Olfr90 by targeting the MAPK pathway. This can lead to the down-regulation of olfactory receptor function and the modulation of odor perception. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine is known to block dopamine receptors, potentially indirectly influencing Olfr90 through dopaminergic signaling pathways. This may lead to changes in olfactory receptor function and the perception of specific odors. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I inhibits protein kinase C (PKC), indirectly impacting Olfr90 by blocking PKC activity. This inhibition can disrupt olfactory receptor signaling pathways, potentially leading to the down-regulation of Olfr90-mediated signal transduction and odor perception. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C is an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptors, indirectly influencing Olfr90 by modulating intracellular calcium release. This can affect calcium-dependent signaling pathways associated with olfactory receptor function, potentially influencing odor perception. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2, indirectly affecting Olfr90 by targeting the MAPK pathway. By disrupting this pathway, it may affect Olfr90 function indirectly, as MAPK signaling has connections with olfactory receptor signaling, potentially leading to changes in receptor function and odor perception. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 inhibits calmodulin-dependent protein kinase II (CaMKII), indirectly influencing Olfr90 by blocking CaMKII activity. This inhibition can disrupt olfactory receptor signaling pathways, potentially leading to the down-regulation of Olfr90-mediated signal transduction and odor perception. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 is a blocker of store-operated calcium channels, indirectly influencing Olfr90 by modulating calcium influx. This action can disrupt calcium-dependent signaling pathways associated with olfactory receptor function, potentially affecting odor perception. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a Janus kinase (JAK) inhibitor, indirectly affecting Olfr90 by targeting JAK-mediated signaling pathways. This can lead to the down-regulation of olfactory receptor function and the modulation of odor perception. | ||||||