Olfr877 Inhibitors
Olfr877, a member of the olfactory receptor family, plays a crucial role in the sensory perception of odorant molecules in Mus musculus (house mouse). It is a G-protein-coupled receptor (GPCR) characterized by a seven-transmembrane domain structure. Olfr877 is responsible for recognizing and transducing odorant signals, initiating the neuronal responses that lead to the perception of specific smells. The olfactory receptor gene family, to which Olfr877 belongs, is the largest in the genome, highlighting the fundamental importance of olfaction in the mouse's sensory experience.
The inhibition of Olfr877 can be achieved through various chemical compounds, both direct and indirect. Direct inhibitors, such as Methyl Anthranilate and Forskolin, disrupt Olfr877's function by either binding to the receptor's active site or modulating cAMP levels, thereby competitively inhibiting odorant binding or enhancing receptor activation. Indirect inhibitors, including Pertussis Toxin, Nifedipine, and others, target critical signaling pathways like cAMP, calcium, PI3K/Akt, JAK-STAT, NF-kB, adenylate cyclase, MAPK, RhoA, Wnt, and mTOR, indirectly influencing Olfr877. These compounds lead to altered receptor sensitivity, downstream signaling, gene expression, or cellular processes essential for olfaction, resulting in impaired olfaction perception. These chemical inhibitors provide valuable tools for scientific research into the mechanisms underlying olfactory perception in Mus musculus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin targets the G-protein coupled to Olfr877, inhibiting its activation and downstream signaling. This leads to impaired olfaction due to disrupted signaling. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine interferes with the intracellular calcium signaling pathway, indirectly inhibiting Olfr877 by disrupting calcium-dependent processes crucial for olfaction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that indirectly inhibits Olfr877 by disrupting the PI3K/Akt pathway, affecting receptor activation and olfaction perception. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 targets the JAK-STAT pathway, indirectly inhibiting Olfr877 by disrupting the signaling cascade, leading to altered receptor sensitivity and olfaction perception. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 modulates the NF-kB pathway, indirectly inhibiting Olfr877 by hindering the transcription of olfactory receptor genes, reducing receptor expression. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ 22536 inhibits adenylate cyclase, reducing cAMP production and indirectly affecting Olfr877 by impairing downstream signaling and receptor function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 interferes with the MAPK pathway, indirectly inhibiting Olfr877. It alters the phosphorylation cascade, affecting receptor function and olfaction perception. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin inhibits the GTPase RhoA, indirectly inhibiting Olfr877 by modulating cytoskeletal dynamics critical for olfactory signal transduction. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 disrupts the Wnt signaling pathway, indirectly inhibiting Olfr877 by affecting downstream events, influencing receptor function and olfaction perception. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, indirectly affecting Olfr877 by altering protein synthesis and cellular processes related to olfaction. | ||||||