Olfr649 Inhibitors
Olfr649, a member of the olfactory receptor family, plays a pivotal role in the intricate process of olfactory signal transduction. Situated on the sensory neurons within the olfactory epithelium, Olfr649 is tasked with recognizing and responding to specific odorant molecules, thereby initiating the olfactory perception cascade. Its function involves binding to odorants and triggering a series of intracellular events that culminate in the generation of electrical signals, which are then transmitted to the brain for interpretation as distinct smells. The responsiveness of Olfr649 is tightly regulated by various signaling pathways and cellular processes, ensuring the precision and specificity of olfactory discrimination.
The inhibition of Olfr649 involves the strategic modulation of key cellular and biochemical pathways associated with olfactory signal transduction. These pathways include, but are not limited to, ion channel dynamics, intracellular calcium levels, and crucial signaling cascades like the PI3K/Akt and MAPK pathways. Inhibitors act on these targets to disrupt the finely tuned processes that enable Olfr649 activation. For instance, chemicals targeting ion channels alter the membrane potential of olfactory sensory neurons, influencing their excitability and subsequently diminishing the receptor's responsiveness to odor stimuli. Similarly, inhibitors of the PI3K/Akt and MAPK pathways interfere with the intracellular signaling events that are essential for Olfr649 activation, leading to an overall inhibition of olfactory perception. The diverse set of inhibitors presented in the table collectively elucidates the multifaceted mechanisms by which Olfr649 can be modulated, providing valuable insights into the intricacies of olfactory signal transduction and the potential avenues for manipulating this process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride, a sodium channel inhibitor, modulates olfactory signaling by affecting ion channels associated with the olfactory sensory neurons. It disrupts sodium influx, influencing membrane potential and altering the excitability of neurons involved in olfactory signal transduction. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1, a V-ATPase inhibitor, perturbs intracellular pH regulation. By inhibiting V-ATPase, it disrupts the acidic environment crucial for proper functioning of olfactory receptor cells, leading to impaired signal transduction and diminished olfactory perception. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP, an uncoupling agent targeting mitochondrial complex V, interferes with cellular respiration. Its action on mitochondrial function indirectly impacts olfactory signal transduction by altering cellular energy dynamics, influencing the responsiveness of olfactory sensory neurons to odor stimuli. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, disrupts the PI3K/Akt signaling pathway. Its inhibition of this pathway modulates intracellular signaling events crucial for olfactory receptor activation, thereby influencing the olfactory response to specific odorants. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK1/2 inhibitor, disrupts the MAPK signaling pathway. By targeting this key pathway associated with olfactory signal transduction, U0126 modulates downstream events, impacting the cellular response to odor stimuli and contributing to the inhibition of Olfr649. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93, a CaMKII inhibitor, modulates calcium-dependent signaling. By inhibiting CaMKII, it disrupts intracellular calcium dynamics, affecting events crucial for olfactory signal transduction. This results in altered responsiveness of olfactory sensory neurons to specific odorants and inhibition of Olfr649. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Calpeptin, a calpain inhibitor, influences intracellular signaling cascades by modulating calpain activity. Its impact on cellular processes associated with olfactory signal transduction leads to altered responsiveness of olfactory sensory neurons to odor stimuli, contributing to the inhibition of Olfr649. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, disrupts the PI3K/Akt signaling pathway. Its inhibition of this pathway influences intracellular signaling events crucial for olfactory receptor activation, leading to modulated olfactory responses and contributing to the inhibition of Olfr649. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365, a non-specific calcium channel inhibitor, perturbs intracellular calcium dynamics. Its action on calcium channels crucial for olfactory signal transduction results in altered responsiveness of olfactory sensory neurons to specific odorants, contributing to the inhibition of Olfr649. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, modulates intracellular calcium levels. Its action on calcium dynamics crucial for olfactory signal transduction leads to altered responsiveness of olfactory sensory neurons to specific odorants, contributing to the inhibition of Olfr649. | ||||||