Olfr55 Inhibitors
Olfr55, a member of the olfactory receptor family, holds a pivotal role in the intricate process of olfactory signal transduction. Functionally, Olfr55 acts as a molecular sensor, initiating complex signaling cascades upon binding to specific odorant molecules. The activation of Olfr55 is tightly regulated by various intracellular signaling pathways, including the MAPK, PI3-kinase, and NF-κB pathways.
The inhibition of Olfr55 involves a sophisticated interplay with these signaling cascades. Chemical inhibitors such as SB203580 and PD98059 target the MAPK pathway, disrupting phosphorylation events crucial for Olfr55 function. Compounds like LY294002 and Wortmannin act as PI3-kinase inhibitors, hindering intracellular signaling by blocking PI3-kinase activity. NF-κB inhibitors such as BAY 11-7082 and JSH-23 modulate the NF-κB pathway, influencing Olfr55 function by inhibiting NF-κB activation. The multifaceted inhibition of Olfr55 showcases the complexity of its regulatory mechanisms, offering valuable insights into potential strategies for controlling olfactory signal transduction. In summary, Olfr55 plays a crucial role as a molecular sensor in olfactory perception, and its inhibition involves targeted interventions in key signaling pathways, unraveling the intricate molecular mechanisms governing olfactory receptor function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor affecting the MAPK pathway linked to Olfr55. Modulates intracellular signaling by inhibiting p38 MAPK activity, hindering downstream cascades crucial for Olfr55 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3-kinase inhibitor affecting the PI3-kinase pathway linked to Olfr55. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr55 function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB inhibitor affecting the NF-κB pathway linked to Olfr55. Modulates intracellular signaling by inhibiting NF-κB activation, hindering downstream cascades crucial for Olfr55 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK inhibitor affecting the MAPK pathway linked to Olfr55 activation. Alters phosphorylation events crucial for Olfr55 function, hindering downstream signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3-kinase inhibitor affecting the PI3-kinase pathway linked to Olfr55. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr55 function. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
NF-κB inhibitor affecting the NF-κB pathway linked to Olfr55. Modulates intracellular signaling by inhibiting NF-κB activation, hindering downstream cascades crucial for Olfr55 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor affecting the MAPK pathway linked to Olfr55 activation. Alters phosphorylation events crucial for Olfr55 function, hindering downstream signaling. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $193.00 | 4 | |
PI3-kinase inhibitor affecting the PI3-kinase pathway linked to Olfr55. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr55 function. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $312.00 | 1 | |
IKK inhibitor affecting the NF-κB pathway linked to Olfr55. Modulates intracellular signaling by inhibiting IKK activity, hindering downstream cascades crucial for Olfr55 function. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
MEK inhibitor affecting the MAPK pathway linked to Olfr55 activation. Alters phosphorylation events crucial for Olfr55 function, hindering downstream signaling. | ||||||