Olfr517 Inhibitors
Olfr517, a key member of the olfactory receptor family, plays a critical role in the intricate process of olfaction by contributing to the detection and transduction of specific odorants. Situated within the olfactory epithelium, Olfr517 acts as a molecular sensor, initiating the conversion of chemical stimuli into neuronal signals essential for the perception of diverse odors. Its presence underscores the significance of this olfactory receptor in shaping the sensory experience associated with odor recognition.
The inhibition of Olfr517 encompasses a sophisticated interplay of direct and indirect mechanisms orchestrated by a diverse array of chemicals. Direct inhibitors, such as Staurosporine, act on protein kinases intricately associated with Olfr517, disrupting downstream signaling pathways and resulting in the direct inhibition of olfactory receptor activation. In contrast, indirect inhibitors, exemplified by Tyrphostin B42 and LY294002, modulate broader signaling pathways like JAK/STAT and PI3K/Akt, respectively. These indirect inhibitors influence downstream events, thereby affecting olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. The intricate strategies employed by these inhibitors highlight the complexity of Olfr517's role in olfaction, emphasizing the need to comprehend both direct and indirect mechanisms for a comprehensive understanding of inhibiting this olfactory receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a direct inhibitor of Olfr517, acting on protein kinases. Its inhibition of kinases disrupts downstream signaling pathways associated with Olfr517, leading to the direct inhibition of olfactory receptor activation and subsequent responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is an indirect inhibitor influencing Olfr517 by targeting the JAK/STAT signaling pathway. Its inhibition of JAK2 modulates downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an indirect inhibitor that affects Olfr517 by targeting the PI3K/Akt signaling pathway. Its interference with this pathway disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as an indirect inhibitor of Olfr517 by targeting phosphoinositide 3-kinases (PI3K). Its action on PI3K disrupts signaling cascades, influencing olfactory signal transduction and resulting in the indirect inhibition of Olfr517-mediated responses. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 provides indirect inhibition of Olfr517 by targeting calmodulin-dependent protein kinase II (CaMKII). Its inhibition of CaMKII disrupts downstream signaling cascades, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 is an indirect inhibitor acting on p38 MAP kinase, associated with Olfr517 signaling. Its modulation of p38 MAP kinase disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 indirectly inhibits Olfr517 by targeting the autophagy pathway. Its inhibition of autophagy disrupts cellular processes associated with Olfr517 function, leading to the indirect inhibition of olfactory signal transduction and receptor activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an indirect inhibitor affecting Olfr517 by targeting Src family kinases. Its action on Src kinases disrupts downstream signaling cascades, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $67.00 $539.00 | ||
CAY10512 indirectly inhibits Olfr517 by modulating the NF-κB signaling pathway. Its action on NF-κB disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an indirect inhibitor influencing Olfr517 by targeting the MEK/ERK signaling pathway. Its modulation of MEK disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr517-mediated responses. | ||||||