Olfr514 Inhibitors
Olfr514, a member of the olfactory receptor family, stands as a pivotal player in the intricate orchestration of olfaction, where it takes part in detecting and transducing specific odorants. Located within the olfactory epithelium, Olfr514 functions as a molecular sensor, initiating the conversion of chemical stimuli into neuronal signals crucial for the perception of a diverse array of odors. The nuanced dance of molecular events orchestrated by Olfr514 underscores its critical role in the sensory experience of odor recognition.
The inhibition of Olfr514 unfolds through a diverse array of direct and indirect mechanisms governed by various chemicals. Direct inhibitors, exemplified by Staurosporine, act on protein kinases intricately associated with Olfr514, resulting in the disruption of downstream signaling and the direct inhibition of olfactory receptor activation. In contrast, indirect inhibitors like AG-490 and LY294002 target broader signaling pathways such as JAK/STAT and PI3K/Akt, respectively. Their actions modulate downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. This intricate tapestry of inhibitory strategies reflects the complexity of Olfr514's role in olfaction, emphasizing the importance of comprehending both direct and indirect mechanisms to unravel the intricacies of inhibiting this olfactory receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a direct inhibitor of Olfr514, acting on protein kinases. Its inhibition of kinases disrupts downstream signaling pathways associated with Olfr514, leading to the direct inhibition of olfactory receptor activation and subsequent responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 is an indirect inhibitor influencing Olfr514 by targeting the JAK/STAT signaling pathway. Its inhibition of JAK2 modulates downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an indirect inhibitor that affects Olfr514 by targeting the PI3K/Akt signaling pathway. Its interference with this pathway disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin acts as an indirect inhibitor of Olfr514 by targeting phosphoinositide 3-kinases (PI3K). Its action on PI3K disrupts signaling cascades, influencing olfactory signal transduction and resulting in the indirect inhibition of Olfr514-mediated responses. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 provides indirect inhibition of Olfr514 by targeting calmodulin-dependent protein kinase II (CaMKII). Its inhibition of CaMKII disrupts downstream signaling cascades, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580 is an indirect inhibitor acting on p38 MAP kinase, associated with Olfr514 signaling. Its modulation of p38 MAP kinase disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 indirectly inhibits Olfr514 by targeting the autophagy pathway. Its inhibition of autophagy disrupts cellular processes associated with Olfr514 function, leading to the indirect inhibition of olfactory signal transduction and receptor activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an indirect inhibitor affecting Olfr514 by targeting Src family kinases. Its action on Src kinases disrupts downstream signaling cascades, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $68.00 $550.00 | ||
CAY10512 indirectly inhibits Olfr514 by modulating the NF-κB signaling pathway. Its action on NF-κB disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an indirect inhibitor influencing Olfr514 by targeting the MEK/ERK signaling pathway. Its modulation of MEK disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr514-mediated responses. | ||||||