Olfr512 Inhibitors
Olfr512, belonging to the olfactory receptor family, holds a crucial role in the intricate process of olfaction by participating in the detection and transduction of specific odorants. This receptor, situated within the olfactory epithelium, functions as a molecular sensor, initiating the conversion of chemical stimuli into neuronal signals that contribute to the perception of diverse odors. The intricate molecular dance orchestrated by Olfr512 in olfactory signal transduction highlights its significance in the sensory experience of odor recognition.
The inhibition of Olfr512 involves a spectrum of direct and indirect mechanisms orchestrated by various chemicals. Direct inhibitors, exemplified by Staurosporine, act on protein kinases associated with Olfr512, resulting in the disruption of downstream signaling and the direct inhibition of olfactory receptor activation. On the other hand, indirect inhibitors, such as Tyrphostin B42 and LY294002, target broader signaling pathways like JAK/STAT and PI3K/Akt, respectively. Their actions modulate downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. This variety of inhibitory strategies reflects the complexity of Olfr512's role in olfaction and emphasizes the importance of understanding both direct and indirect mechanisms to unravel the intricacies of inhibiting this olfactory receptor.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a direct inhibitor of Olfr512, acting on protein kinases. Its inhibition of kinases disrupts downstream signaling pathways associated with Olfr512, leading to the direct inhibition of olfactory receptor activation and subsequent responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is an indirect inhibitor influencing Olfr512 by targeting the JAK/STAT signaling pathway. Its inhibition of JAK2 modulates downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an indirect inhibitor that affects Olfr512 by targeting the PI3K/Akt signaling pathway. Its interference with this pathway disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as an indirect inhibitor of Olfr512 by targeting phosphoinositide 3-kinases (PI3K). Its action on PI3K disrupts signaling cascades, influencing olfactory signal transduction and resulting in the indirect inhibition of Olfr512-mediated responses. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 provides indirect inhibition of Olfr512 by targeting calmodulin-dependent protein kinase II (CaMKII). Its inhibition of CaMKII disrupts downstream signaling cascades, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 is an indirect inhibitor acting on p38 MAP kinase, associated with Olfr512 signaling. Its modulation of p38 MAP kinase disrupts downstream events, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 indirectly inhibits Olfr512 by targeting the autophagy pathway. Its inhibition of autophagy disrupts cellular processes associated with Olfr512 function, leading to the indirect inhibition of olfactory signal transduction and receptor activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an indirect inhibitor affecting Olfr512 by targeting Src family kinases. Its action on Src kinases disrupts downstream signaling cascades, influencing olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $67.00 $539.00 | ||
CAY10512 indirectly inhibits Olfr512 by modulating the NF-κB signaling pathway. Its action on NF-κB disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an indirect inhibitor influencing Olfr512 by targeting the MEK/ERK signaling pathway. Its modulation of MEK disrupts downstream events, affecting olfactory signal transduction and leading to the indirect inhibition of Olfr512-mediated responses. | ||||||