Olfr480 Inhibitors
Olfr480, a prominent olfactory receptor, stands at the forefront of olfactory sensory perception, playing a pivotal role in the intricate mechanism of odor detection. Positioned within olfactory sensory neurons, Olfr480 is a G protein-coupled receptor (GPCR) designed to recognize and transduce signals from specific odorant molecules. The activation of Olfr480 initiates a cascade of molecular events, facilitating the transmission of olfactory signals to the brain and enabling the nuanced discrimination of diverse odors.
The inhibition of Olfr480 involves a complex interplay with various cellular pathways, each contributing to the modulation of its expression. Direct inhibitors disrupt specific signaling cascades associated with Olfr480, such as the cAMP signaling pathway and chromatin remodeling processes, altering the receptor's expression indirectly. Moreover, modulation of key signaling pathways, including the MAPK, calcium-dependent, PI3K/Akt/mTOR, GPCR-mediated, NF-κB, JAK/STAT, Wnt, AMPK, TLR, and Notch pathways, serves as a mechanism for Olfr480 inhibition. These pathways intricately regulate cellular processes and signaling events, exerting influence on Olfr480 expression indirectly. The dynamic orchestration of these molecular interactions reflects the sophisticated regulatory network that governs Olfr480, shedding light on the intricate mechanisms behind olfactory sensory perception and receptor modulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Phosphodiesterase 4 inhibitor disrupting cAMP signaling. Increased cAMP levels alter Olfr480 expression indirectly by modulating downstream pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor impacting chromatin remodeling. Alters the epigenetic landscape, affecting Olfr480 expression by influencing the accessibility of its promoter. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK inhibitor targeting the MAPK pathway. Indirectly inhibits Olfr480 by altering the phosphorylation state of proteins in the signaling cascade, impacting gene expression. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Calcium channel blocker disrupting intracellular calcium levels. Indirectly influences Olfr480 by interfering with calcium-dependent signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor affecting Akt/mTOR pathway. Alters Olfr480 expression indirectly through the modulation of downstream effectors in the PI3K signaling cascade. | ||||||
Olanzapine | 132539-06-1 | sc-212469 | 100 mg | $133.00 | 6 | |
GPCR antagonist targeting receptors upstream of Olfr480. Modulates signal transduction, indirectly inhibiting Olfr480 expression by interfering with receptor activation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB inhibitor attenuating inflammatory signaling. Indirectly inhibits Olfr480 expression by suppressing NF-κB-mediated transcriptional regulation. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK/STAT pathway inhibitor. Modulates Olfr480 expression indirectly by disrupting cytokine signaling through the inhibition of JAK and STAT signaling components. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Wnt pathway antagonist. Indirectly inhibits Olfr480 by interfering with the Wnt signaling cascade, impacting downstream events involved in gene expression. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activator influencing energy sensing. Indirectly inhibits Olfr480 by regulating cellular energy status, affecting pathways linked to gene expression. | ||||||