Olanzapine (CAS 132539-06-1)
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Olanzapine is a compound that has become a subject of interest in various research domains beyond its primary recognized uses. In the field of pharmacology, it is studied for its binding affinity to multiple neurotransmitter receptors, which provides insights into receptor function and the interplay between different neurotransmitter systems. Behavioral scientists use olanzapine in models to study the effects of receptor modulation on behavior, which can include the investigation of stress responses, cognitive functions, and social interactions. Furthermore, olanzapine is utilized in neurochemical research to examine the downstream effects of receptor engagement, such as changes in neurotransmitter release, second messenger system activity, and gene expression patterns. It also serves as a reference compound in analytical studies for the development of detection methods and the establishment of pharmacokinetic profiles.
Olanzapine (CAS 132539-06-1) References
- Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways. | Lu, XH. and Dwyer, DS. 2005. J Mol Neurosci. 27: 43-64. PMID: 16055946
- Distinct functional profiles of aripiprazole and olanzapine at RNA edited human 5-HT2C receptor isoforms. | Zhang, JY., et al. 2006. Biochem Pharmacol. 71: 521-9. PMID: 16336943
- Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts. | Tulipano, G., et al. 2008. Mol Cell Endocrinol. 292: 42-9. PMID: 18514390
- Hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine. | Davoodi, N., et al. 2009. Psychopharmacology (Berl). 203: 693-702. PMID: 19052729
- Effects of olanzapine and clozapine on radial maze performance in naive and MK-801-treated mice. | Mutlu, O., et al. 2012. Arzneimittelforschung. 62: 4-8. PMID: 22331755
- Olanzapine-induced hyperglycemia: possible involvement of histaminergic, dopaminergic and adrenergic functions in the central nervous system. | Ikegami, M., et al. 2013. Neuroendocrinology. 98: 224-32. PMID: 24135197
- Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line. | Mokros, Ł., et al. 2016. Biol Rhythm Res. 47: 865-871. PMID: 27746588
- Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate. | He, M., et al. 2019. Psychoneuroendocrinology. 104: 286-299. PMID: 30927713
- Olanzapine-mediated cardiotoxicity is associated with altered energy metabolism in isolated rat hearts. | Gulac, P., et al. 2020. Acta Biochim Pol. 67: 15-23. PMID: 31999421
- Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice. | Chen, X., et al. 2020. Psychoneuroendocrinology. 114: 104594. PMID: 32007669
- N-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons. | Boz, Z., et al. 2020. Sci Rep. 10: 19185. PMID: 33154380
- NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist. | He, M., et al. 2022. Front Aging Neurosci. 14: 847561. PMID: 35615587
- A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism. | Torii-Goto, A., et al. 2022. Biol Pharm Bull. 45: 1232-1237. PMID: 36047190
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Olanzapine, 100 mg | sc-212469 | 100 mg | $133.00 |