Olfr480 Activators
Chemical activators of Olfr480 include a range of volatile organic compounds, primarily found in natural sources like fruits, plants, and oils. These activators, such as Isoamyl acetate, Limonene, and Eugenol, interact directly with Olfr480, a G-protein-coupled receptor (GPCR), typical of olfactory receptors. Upon binding to Olfr480, these chemicals induce a conformational change in the receptor structure, initiating a cascade of intracellular events. The primary pathway involved in this activation is the GPCR signaling mechanism, which leads to the production of second messengers such as cyclic AMP. The increase in cyclic AMP is a critical step in olfactory signal transduction, as it triggers a series of reactions that culminate in the generation of a neural signal, conveying the olfactory information to the brain.
Other compounds like Methyl salicylate, Vanillin, and Benzaldehyde function similarly, binding to Olfr480 and activating the GPCR pathway. This consistent mechanism across various chemicals emphasizes the receptor's role in detecting a wide range of scents. Each activator has a unique molecular structure that allows specific interaction with Olfr480, triggering the receptor's activation. This specificity is crucial for the diverse range of odor detection and recognition in the olfactory system. The activation of Olfr480 by these chemicals demonstrates the complex and highly specialized nature of olfactory receptors in processing a multitude of olfactory stimuli, enabling the perception of various scents. The interaction of these activators with Olfr480 underscores the intricate molecular dynamics involved in olfactory perception and the sophisticated nature of GPCR-mediated signal transduction in the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate, commonly found in bananas and pears, can activate Olfr480 by binding directly to the receptor site, triggering a conformational change. This interaction initiates the G-protein-coupled receptor (GPCR) pathway, leading to the activation of adenylate cyclase and an increase in cyclic AMP levels, ultimately resulting in olfactory signal transduction. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a major component of citrus oil, may activate Olfr480 by direct interaction with its binding site. This binding induces a structural alteration in the receptor, activating the associated GPCR pathway. This activation stimulates the production of cyclic AMP, further leading to the generation of a neural signal in olfactory neurons. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, found in clove oil, likely activates Olfr480 through direct binding. This interaction facilitates the activation of the GPCR mechanism, leading to the production of second messengers like cyclic AMP, which play a crucial role in the olfactory signaling cascade. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, with a wintergreen scent, can activate Olfr480 by binding to its active site. This interaction triggers the GPCR cascade, resulting in the elevation of cyclic AMP and the subsequent activation of the olfactory signal transduction pathway. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, the primary component of vanilla bean extract, activates Olfr480 by directly binding to the receptor. This interaction stimulates the GPCR pathway, increasing cyclic AMP levels and thereby facilitating the transmission of olfactory signals. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate, commonly found in pineapples, can activate Olfr480 by binding to its ligand-binding domain. This interaction activates the associated GPCR pathway, leading to an increase in cyclic AMP, which plays a vital role in the olfactory signal transduction mechanism. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, present in lemongrass, is likely to activate Olfr480 by direct binding. This interaction initiates the GPCR signaling pathway, resulting in increased cyclic AMP levels and the activation of the olfactory signaling pathway. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a component of rose oil, may activate Olfr480 through direct receptor interaction. This binding induces GPCR pathway activation, culminating in an increase in cyclic AMP and the facilitation of olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, found in lavender, can activate Olfr480 by directly interacting with the receptor, triggering the GPCR cascade. This leads to increased cyclic AMP levels, essential for the transmission of olfactory signals. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, with a grassy odor, potentially activates Olfr480 through direct binding to the receptor, triggering the GPCR pathway. This activation results in elevated cyclic AMP levels, essential for olfactory signal transduction. | ||||||