Olfr459 Inhibitors
Olfr459, a crucial member of the olfactory receptor family, orchestrates the initiation of neuronal responses to odorant molecules, leading to the perception of smell. As a G-protein-coupled receptor (GPCR), Olfr459 shares structural features with neurotransmitter and hormone receptors, playing a pivotal role in the intricate process of odorant signal transduction. The olfactory receptor gene family, particularly exemplified by Olfr459, constitutes the largest in the genome, underlining its significance in olfactory perception.
Inhibition of Olfr459 involves a diverse set of chemical interventions targeting various GPCR-associated pathways. Forskolin enhances cAMP levels, indirectly inhibiting Olfr459 by modulating cAMP-dependent processes in olfactory signal transduction. U0126 and PD98059, MEK inhibitors, disrupt the MAPK pathway, potentially inhibiting Olfr459 function through downstream modulation of the MAPK cascade. Thapsigargin, a SERCA pump inhibitor, influences calcium signaling, impacting Olfr459 through calcium-dependent processes. Additionally, NF-κB inhibitor modulates NF-κB signaling, affecting GPCR-related pathways, while Wortmannin inhibits PI3-kinase, disrupting PI3-kinase-dependent processes involved in Olfr459-mediated signal transduction. Suramin acts as a non-specific antagonist, potentially disrupting olfactory receptor protein function. These inhibitors offer valuable insights into potential interventions for Olfr459, providing a nuanced understanding of the intricate mechanisms involved in olfactory signal transduction at the molecular level.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
SIRT1 activator influencing cellular processes associated with olfactory signal transduction. Indirectly inhibits Olfr459 by promoting SIRT1-dependent deacetylation events that impact downstream GPCR signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator enhancing cAMP levels and influencing GPCR signaling. Indirectly inhibits Olfr459 by modulating cAMP-dependent processes that play a role in olfactory signal transduction. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor affecting the MAPK pathway. Alters GPCR-related signal transduction, potentially inhibiting Olfr459 function through downstream modulation of the MAPK cascade. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $42.00 $126.00 | 10 | |
Intracellular calcium chelator affecting GPCR-mediated signal transduction. Alters calcium-dependent processes, indirectly influencing Olfr459 function by modulating downstream signaling cascades. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor disrupting MAPK pathway. Influences GPCR-mediated signal transduction, potentially inhibiting Olfr459 function through the downstream modulation of MAPK signaling. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
Modulator of NF-κB signaling impacting GPCR-related pathways. Alters intracellular processes, potentially inhibiting Olfr459 function through the disruption of NF-κB-mediated cascades involved in olfactory signal transduction. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor altering intracellular signaling pathways. Indirectly influences olfactory receptor function by disrupting PI3-kinase-dependent processes involved in GPCR-mediated signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor influencing calcium signaling. Disrupts GPCR-related pathways by modulating intracellular calcium levels, potentially impacting Olfr459 function through calcium-dependent processes in olfactory signal transduction. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Polyanionic compound interfering with GPCR signaling cascades. Acts as a non-specific antagonist, potentially disrupting olfactory receptor protein function through downstream effects on G protein pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor impacting MAPK signaling pathways. Modulates cellular responses downstream of GPCR activation, potentially inhibiting Olfr459 function through the MAPK cascade. | ||||||