Olfr459 Activators
Chemical activators of Olfr459, such as Octyl acetate, Benzaldehyde, and Cinnamaldehyde, function by directly interacting with the ligand-binding domain of the protein. These chemicals induce conformational changes in Olfr459, essential for activating the G-protein coupled receptor (GPCR) pathway. Binding of these activators results in the stimulation of adenylate cyclase, which subsequently elevates intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA) and other downstream signaling molecules, leading to various cellular responses.
Chemicals including Ethyl hexanoate, Amyl acetate, and Isoamyl alcohol share a common mechanism in activating Olfr459. They bind to specific sites on the protein, initiating a cascade of intracellular events. This binding alters the protein conformation, effectively triggering the GPCR pathway. Activation of this pathway leads to a series of intracellular reactions, primarily the production of cAMP. This signaling molecule plays a central role in activating downstream effectors, thus propagating the signal initiated by the chemical activators. The downstream effects of these signaling pathways culminate in physiological responses, demonstrating the direct impact these chemical activators have on the functional activity of Olfr459.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Octyl acetate | 112-14-1 | sc-236244 | 5 g | $24.00 | ||
Octyl acetate activates Olfr459 by directly binding to its ligand-binding domain, causing a conformational change in Olfr459. This interaction initiates signal transduction via G-protein coupled receptors, leading to increased intracellular cAMP levels and subsequent cellular responses. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamic Aldehyde activates Olfr459 by directly binding to its odorant recognition site, promoting the G-protein coupled receptor pathway, increasing cAMP production, and activating protein kinase A, leading to signal transduction processes. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $50.00 | ||
Ethyl hexanoate selectively activates Olfr459 by interacting with its odorant binding domain. This interaction enhances G-protein coupling and activates adenylate cyclase, resulting in elevated cAMP levels and initiating intracellular signaling events. | ||||||
Pentyl acetate | 628-63-7 | sc-215691 | 250 ml | $65.00 | ||
Pentyl acetate directly activates Olfr459 by binding to its ligand-binding domain, triggering a signaling cascade via G-protein activation, stimulating adenylate cyclase, increasing cAMP levels, and activating downstream signaling pathways. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $70.00 $93.00 | ||
3-Methyl-1-butanol activates Olfr459 by directly interacting with its ligand-binding site, inducing a conformational change that facilitates G-protein coupled receptor pathway activation, increasing cAMP, and activating subsequent signaling mechanisms. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr459 by binding to its specific odorant receptor site, inducing a structural alteration in the protein. This change triggers G-protein signaling activation, enhancing cAMP production, and activating downstream effector molecules. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate activates Olfr459 by interacting with its specific odorant binding domain, facilitating the activation of G-protein coupled receptor pathways, increasing cAMP levels, and activating downstream signaling pathways, including protein kinase A activation. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
(±)-β-Citronellol directly activates Olfr459 by binding to its ligand recognition site, triggering a conformational change leading to G-protein signaling pathways activation, an increase in intracellular cAMP levels, and subsequent activation of downstream cellular responses. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $29.00 $41.00 $71.00 $122.00 | ||
4-Methoxybenzaldehyde activates Olfr459 by binding to its specific ligand-binding domain, facilitating the activation of G-protein coupled receptor mechanisms, leading to the elevation of cAMP levels, and triggering a cascade of intracellular signaling pathways and cellular responses. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates Olfr459 through direct interaction with its odorant recognition site, initiating a signaling cascade through G-protein activation, promoting an increase in cAMP levels, and leading to the activation of downstream signaling pathways and physiological responses. | ||||||