Oct-2 Inhibitors
Common Oct-2 Inhibitors include, but are not limited to Probenecid CAS 57-66-9, Cimetidine CAS 51481-61-9, Trimethoprim CAS 738-70-5, Verapamil hydrochloride CAS 152-11-4 and Famotidine CAS 76824-35-6.
Oct-2 inhibitors constitute a category of chemical compounds designed to selectively interact with and modulate the activity of Oct-2, a transcription factor belonging to the POU domain family. Oct-2, also known as POU2F2, is an essential factor involved in the regulation of gene expression, particularly in the context of immune response and B-cell development. It plays a pivotal role in initiating transcription by binding to specific DNA sequences known as octamer motifs, which are present in the promoters of various target genes.
These inhibitors are designed to disrupt the interactions between Oct-2 and its target DNA sequences, affecting the transcriptional activity of downstream genes. By specifically targeting Oct-2, researchers aim to elucidate the intricate mechanisms underlying B-cell development, immune response regulation, and the broader impact on cellular functions. The study of Oct-2 inhibitors provides valuable insights into the complex network of transcription factors that govern gene expression and cellular processes, contributing to a deeper understanding of immune system functionality and molecular pathways involved in immune-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Organic anion transporter inhibitor that competes with endogenous substrates for OCT-2 binding. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Histamine H2 receptor antagonist that competitively inhibits OCT-2-mediated transport of organic cations. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $66.00 $158.00 $204.00 $707.00 $3334.00 | 4 | |
Antibiotic that interferes with OCT-2 activity and the transport of organic cations. | ||||||
Famotidine | 76824-35-6 | sc-205691 sc-205691A | 500 mg 1 g | $64.00 $109.00 | ||
H2 histamine receptor antagonist that might interfere with OCT-2 function and substrate transport. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $38.00 $144.00 | ||
Antiviral agent that interacts with OCT-2, potentially influencing the transport of cationic drugs. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Investigated for its antiarrhythmic properties, Quinidine competes with other substrates for OCT-2 binding and transport. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
Histamine H2 receptor antagonist that could potentially impact OCT-2 activity and cationic transport. | ||||||
Naloxone | 465-65-6 | sc-477809 | 200 mg | $300.00 | 5 | |
Opioid receptor antagonist that has been reported to interact with OCT-2-mediated transport. | ||||||
Cefotiam | 61622-34-2 | sc-278821 | 100 mg | $700.00 | ||
Antibiotic that can inhibit OCT-2, potentially affecting the transport of cationic compounds. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Antidiabetic sulfonylurea that could impact OCT-2 function and substrate transport. | ||||||