Glyburide (Glibenclamide) CAS: 10238-21-8
MF: C23H28ClN3O5S
MW: 494.0
An ATP-dependent KIR6 and CFTR Cl- channel blocker.

Glyburide (Glibenclamide) (CAS 10238-21-8)

Glyburide (Glibenclamide) | CAS 10238-21-8 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
Application: Glyburide (Glibenclamide) is an ATP-dependent KIR6 and CFTR Cl- channel blocker
CAS Number: 10238-21-8
Purity: ≥98%
Molecular Weight: 494.0
Molecular Formula: C23H28ClN3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 μM).


References

1. Schmid-Antomarchi, H., et al. 1987. J. Biol. Chem. 262: 15840-15844. PMID: 2445740
2. Fosset, M., et al. 1988. J. Biol. Chem. 263: 7933-7936. PMID: 2453509
3. Winquist, R.J., et al. 1989. J. Pharmacol. Exp. Ther. 248: 149-156. PMID: 2464055
4. Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256: 358-364. PMID: 1899120
5. Serrano-Martín, X., et al. 2006. Antimicrob. Agents Chemother. 50: 4214-4216. PMID: 17015627

Usage :
Stock solutions are stable for up to 3 months at -20°C.
Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
173-175° C
Boiling Point :
708.87° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
recombinant CFTR Cl- channels: IC50 = 20 µM
Ki Data :
Sulfonylurea receptor 2: Ki= 130 nM (human); Potassium channel, inwardly rectifying, subfamily J, member 8: Ki= 0.61 nM (Rattus norvegicus)
pK Values :
pKa: 5.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
YS4725200
PubChem CID :
3488
Merck Index :
14: 4478
MDL Number :
MFCD00056625
EC Number :
233-570-6
SMILES :
COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Download SDS (MSDS)

Certificate of Analysis

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Glyburide (Glibenclamide) (CAS 10238-21-8)  Product Citations

See how others have used Glyburide (Glibenclamide) (CAS 10238-21-8). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 28272433  Orfi, Z. et al. 2017. Sci Rep. 7: 44073.

PMID: # 27872020  Li, SL. et al. 2017. Pharmacol. Res. 115: 78-86.

PMID: # 28245258  Asensio-López, MC. et al. 2017. PLoS ONE. 12: e0172803.

PMID: # 27827428  Fujii, S. et al. 2016. Sci Rep. 6: 36795.

PMID: # 25932125  Kong, JJ. et al. 2015. Int J Clin Exp Med. 8: 1966-75.

PMID: # 26225433  Lahmann, C. et al. 2015. PLoS ONE. 10: e0134476.

PMID: # 26028562  Gurgul-Convey, E. et al. 2015. Biochem. Biophys. Res. Commun. 464: 13-9.

PMID: # 24691785  Kim, J. et al. 2014. Vet. Res. Commun. 38: 193-200.

PMID: # 24613832  Fitzgerald, R. et al. 2014. Biochem. Biophys. Res. Commun. 446: 393-8.

PMID: # 24718754  Changklungmoa, N. et al. 2014. Parasitol. Res. 113: 2335-43.

Citations 1 to 10 of 22 total
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Rated 5 out of 5 by from Glyburide is used clinically to treat diabetes Glyburide is used clinically to treat diabetes (non-SCBT source). Ghanim, et. al. (PubMed ID 18556339) studied the modulation of Toll-Like Receptors by Insulin in patient samples who were treated with either glyburide or metformin. -SCBT Publication Review
Date published: 2015-01-04
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