Oct-2 Activators
Common Oct-2 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Curcumin CAS 458-37-7, Resveratrol CAS 501-36-0, Forskolin CAS 66575-29-9 and 5-Aza-2′-Deoxycytidine CAS 2353-33-5.
Oct-2 activators are compounds that stimulate the activity or expression of Oct-2, a transcription factor belonging to the POU (Pit-Oct-Unc) family of proteins. Oct-2, with its characteristic POU domain, plays a crucial role in the regulation of gene expression, particularly in the immune system. Specifically, Oct-2 is predominantly expressed in B cells, where it modulates the transcription of genes essential for B cell differentiation and function.
The activity of Oct-2 is characterized by its ability to bind specific DNA sequences, known as octamer motifs, within the promoters or enhancers of target genes. This binding is facilitated by the POU domain, which provides specificity and affinity for these DNA sequences. Upon binding, Oct-2 can recruit various cofactors and chromatin-modifying enzymes, either promoting or repressing the transcription of target genes, depending on the cellular context and the associated molecular partners. Oct-2 activators, by enhancing the activity or expression of this transcription factor, can modulate the expression of genes under its control, influencing B cell responses and other processes regulated by Oct-2. Given the central role of Oct-2 in B cell biology and immune responses, understanding the mechanisms and implications of Oct-2 activation offers deep insights into the complex regulatory networks governing immune cell function. Exploring the intricacies of Oct-2 activators, and their influence on the transcriptional landscape, sheds light on the broader implications of transcription factor modulation in cellular differentiation, adaptation, and response to external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through its nuclear receptors. It might influence Oct-2 expression indirectly through its transcriptional regulatory roles. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can influence various signaling pathways, potentially impacting Oct-2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol modulates numerous signaling pathways, which could influence Oct-2 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, affecting cAMP levels, which may indirectly modulate Oct-2 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor, it affects gene expression and might alter Oct-2 expression through epigenetic changes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it can alter gene expression and could indirectly modulate Oct-2 expression through its effect on chromatin remodeling. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
E2 regulates numerous genes and might affect Oct-2 expression through estrogen receptor-mediated pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Known to influence various signaling pathways and may impact Oct-2 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A PKC activator, PMA affects multiple cellular pathways and might impact Oct-2 expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
As a glucose analog, it can affect cellular metabolism and might influence Oct-2 expression due to metabolic shifts. | ||||||