Molecular structure of Famotidine, CAS Number: 76824-35-6
Famotidine (CAS 76824-35-6)
Alternate Names:
Pepcid
Application:
Famotidine is a histamine HRH2 antagonist with IC50 of 0.6 mM
CAS Number:
76824-35-6
Purity:
≥98%
Molecular Weight:
337.45
Molecular Formula:
C8H15N7O2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Famotidine is a compound that has been extensively studied in the context of its interaction with histamine H2 receptors. In research environments, the focus on Famotidine often centers on the elucidation of receptor-ligand interactions within the gastrointestinal system. Investigations into the mechanism of action of Famotidine involve the exploration of how it binds to and influences the activity of H2 receptors, which are implicated in the regulation of gastric acid secretion. Additionally, studies on Famotidine might examine its effects on the signaling pathways and intracellular processes that follow receptor engagement. By understanding the molecular details of its action, researchers aim to shed light on the broader aspects of histamine-mediated physiological processes.
Famotidine (CAS 76824-35-6) References
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- Famotidine inhibits glycogen synthase kinase-3β: an investigation by docking simulation and experimental validation. | Mohammad, M., et al. 2013. J Enzyme Inhib Med Chem. 28: 690-4. PMID: 22512725
- Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs. | Tolbert, MK., et al. 2017. J Vet Intern Med. 31: 117-123. PMID: 27906465
- Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. | Balcomb, CC., et al. 2018. J Vet Intern Med. 32: 1283-1289. PMID: 29572958
- Protective effect of famotidine on ischemia-reperfusion injury following testicular torsion in rats. | Tanriverdi, HI., et al. 2021. J Pediatr Urol. 17: 167.e1-167.e7. PMID: 33046373
- Solubility and thermodynamic analysis of famotidine polymorphs in pure solvents. | Soto, R. and Svärd, M. 2021. Int J Pharm. 607: 121031. PMID: 34419593
- Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm. | Yang, H., et al. 2022. Mol Med. 28: 57. PMID: 35578169
- Promoting Activity of Terpenes on Skin Permeation of Famotidine. | Xu, Q., et al. 2023. Chem Pharm Bull (Tokyo). 71: 111-119. PMID: 36724975
- Comparison of immunomodulative effects of the histamine-2 receptor antagonists cimetidine, ranitidine, and famotidine on peripheral blood mononuclear cells in gastric cancer patients. | Hahm, KB., et al. 1995. Scand J Gastroenterol. 30: 265-71. PMID: 7770717
- Efficacy of famotidine in patients with acute gastric mucosal injury after continuous infusion of cisplatin plus vindesine. | Mori, K., et al. 1995. J Cancer Res Clin Oncol. 121: 367-70. PMID: 7797602
- Occupational allergic contact dermatitis from intermediate products in famotidine synthesis. | Guimaraens, D., et al. 1994. Contact Dermatitis. 31: 259-60. PMID: 7842684
- Famotidine (pepcid)-induced symptomatic dermatographism. | Warner, DM., et al. 1994. J Am Acad Dermatol. 31: 677-8. PMID: 8089301
- Famotidine-induced mixed hepatocellular jaundice. | Ament, PW., et al. 1994. Ann Pharmacother. 28: 40-2. PMID: 8123957
- The tolerability and safety profile of famotidine. | Howden, CW. and Tytgat, GN. 1996. Clin Ther. 18: 36-54; discussion 35. PMID: 8851452
- Famotidine-associated mental status changes. | Rodgers, PT. and Brengel, GR. 1998. Pharmacotherapy. 18: 404-7. PMID: 9545163
Inhibitor of:
ABHD11, Gastrin, Gastrokine 1, Gastrokine 3, GIF, Gm885, H2-Adβ, H2-I, H2RSP, HDC, Histamine H2 Receptor, HRT2, KA2, MATE1, MrgB2, MRGX2, Oct-2, Olfr827, Olfr943, Olr239, Olr32, Pepsin A, Pepsin A3, Pepsin A4, Pepsin C, Pepsinogen A, and T2R23.Activator of:
CCK, LIN-15A, and Mast Cell Protease 4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Famotidine, 500 mg | sc-205691 | 500 mg | $64.00 | |||
Famotidine, 1 g | sc-205691A | 1 g | $109.00 |