OAT6 Inhibitors
Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid-d14 | sc-219644 | 1 mg | $273.00 | |||
Probenecid-d14 demonstrates intriguing interactions with the OAT6 transporter, where its isotopic labeling allows for enhanced tracking of molecular dynamics. The compound's unique structural features promote specific binding affinities, influencing the kinetics of organic anion transport. Its distinct hydrophilic and hydrophobic balance contributes to its solubility profile, offering insights into the mechanisms of substrate selectivity and the modulation of transport pathways in cellular environments. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid can inhibit cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins can modulate renal blood flow, which could affect the function of organic anion transporters like OAT6 by altering the renal excretion process. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid is known to inhibit the OAT family by blocking the transport of organic anions. As OAT6 is an organic anion transporter, probenecid can directly inhibit its activity by competing for its substrate binding sites. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits COX enzymes. By decreasing prostaglandin synthesis, it can influence renal blood flow and consequently the activity of renal organic anion transporters like OAT6. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen acts as a COX inhibitor, leading to reduced synthesis of prostaglandins. This reduction can influence the renal handling of organic anions, thus potentially decreasing the functional activity of OAT6. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan, an angiotensin II receptor antagonist, can influence renal blood flow and glomerular filtration rates. These hemodynamic changes can indirectly inhibit the activity of OAT6 by altering the renal clearance of organic anions. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide is a loop diuretic that inhibits the Na+/K+/2Cl- cotransporter in the kidney. Its diuretic action can lead to changes in urine flow and electrolyte levels, which could indirectly affect OAT6's ability to transport organic anions. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is an H2 receptor antagonist that can inhibit renal secretion of organic anions by competing with them for renal transport systems, including OAT6, thereby decreasing its functional activity. | ||||||
Ketoprofen | 22071-15-4 | sc-205359 sc-205359A | 5 g 25 g | $93.00 $308.00 | 2 | |
Ketoprofen, another COX inhibitor, reduces prostaglandin synthesis, which can affect renal function and thus the activity of OAT6 in the transport of organic anions. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine can inhibit various organic cation transporters and might have similar effects on organic anion transporters like OAT6, by altering the electrochemical gradient required for its function. | ||||||