Molecular structure of Losartan, CAS Number: 114798-26-4
Losartan (CAS 114798-26-4)
See product citations (18)
Alternate Names:
Hyzaar
Application:
Losartan is an AT1 inhibitor which prevents the initiation of a signal cascade which causes vasoconstriction
CAS Number:
114798-26-4
Purity:
≥95%
Molecular Weight:
422.91
Molecular Formula:
C22H23ClN6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Losartan is a potent, non-peptide antagonist of AT1 (angiotensin II receptor, type 1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.
Losartan (CAS 114798-26-4) References
- Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke. | Kjeldsen, SE., et al. 2007. Vasc Health Risk Manag. 3: 299-305. PMID: 17703637
- A systematic review and meta-analysis of candesartan and losartan in the management of essential hypertension. | Zhenfeng Zheng, ., et al. 2011. J Renin Angiotensin Aldosterone Syst. 12: 365-74. PMID: 21421652
- Losartan improves the distribution and efficacy of doxorubicin in CT26 tumor. | Xiao, L., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 3763-9. PMID: 26502868
- Losartan treatment attenuates the development of neuropathic thermal hyperalgesia induced by peripheral nerve injury in rats. | Kalynovska, N., et al. 2019. Life Sci. 220: 147-155. PMID: 30731141
- Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. | He, YL., et al. 2021. Neurourol Urodyn. 40: 137-146. PMID: 33606304
- Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models. | Wu, L., et al. 2021. Sci Transl Med. 13: PMID: 34261799
- Molecular Mechanisms of Hypertensive Nephropathy: Renoprotective Effect of Losartan through Hsp70. | Costantino, VV., et al. 2021. Cells. 10: PMID: 34831368
- Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats. | Coatl-Cuaya, H., et al. 2022. J Chem Neuroanat. 120: 102061. PMID: 34952137
- Randomized placebo-controlled trial of losartan for pediatric NAFLD. | Vos, MB., et al. 2022. Hepatology. 76: 429-444. PMID: 35133671
- Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling. | Yoshihara, T., et al. 2022. J Physiol Sci. 72: 6. PMID: 35264097
- Effects of losartan on bladder dysfunction due to aging-related severe hypertension in rats. | Shimizu, S., et al. 2022. Eur J Pharmacol. 922: 174911. PMID: 35337813
- Effects of losartan and exercise on muscle mass and exercise endurance of old mice. | Lin, CH., et al. 2022. Exp Gerontol. 165: 111869. PMID: 35710057
- Effect of losartan treatment on Smad signaling and recovery from hindlimb unloading-induced soleus muscle atrophy in female rats. | Yoshihara, T., et al. 2022. Eur J Pharmacol. 931: 175223. PMID: 35988789
- Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad. | Zou, J., et al. 2022. Biomed Pharmacother. 149: 112931. PMID: 36068784
- Study of Therapeutic Effects of Losartan for Sarcopenia Based on the F344xBN Rat Aging Model. | Kang, D., et al. 2022. In Vivo. 36: 2740-2750. PMID: 36309386
Inhibitor of:
β-Arrestin-2, δ-sarcoglycan, 1700095B22Rik, AGT1, Aldosterone, ANG III, ANG IV, Angiotensin, Angiotensinase C, ARG-Vasopressin, arginase II, Arrestin-C, AT1, AT1a, BOCT, BPIL1, CAT-4, CD42c, CES2, COL13A1, COL3A1, COL4A3, COL5A3, collectrin, CTL3, D-GPCR, D830046C22Rik, Dear, DGCR14, EG331493, fibrillin-1, fibrillin-3, Gγ 12, GALR3, Glut9, Gm13247, Gm14139, Gm14306, GPR158, HRG-β3, Human Thymic Fibroblasts, kallistatin, Klkb16, LKLF, MAS1L, Mdr-2, Mmgt2, MTUS2, MYH15, Myofibroblasts, Myotrophin, NCKX2, NCKX4, NKAIN1, OAT, OAT3, OAT6, OATP-J, Oatp2, Oatp4, Olfr1, Olfr1012, Olfr1015, Olfr1018, Olfr1023, Olfr1030, Olfr1032, Olfr1039, Olfr1048, Olfr1049, Olfr1051, Olfr1056, Olfr1087, Olfr1095, Olfr1100, Olfr1109, Olfr1111, Olfr1115, Olfr380, Olfr427, Olfr614, Olfr667, Olfr668, Olfr669, Olfr67, Olfr670, Olfr671, Olfr672, Olfr675, Olfr676, Olfr677, Olfr678, Olfr679, Olfr68, Olfr681, Olfr683, Olfr684, Olfr685, Olfr686, Olfr688, Olfr689, Olfr69, Olfr690, Olfr747, Olfr768, Olfr771, Olfr822, Olfr823, Olfr829, Olr1233, Olr14, Olr1462, Olr1472, Olr1499, Olr1511, Olr1514, Olr1517, Olr193, Olr211, Olr222, Olr24, Olr252, Olr257, Olr27, Olr32, Olr395, Olr400, Olr403, Olr413, Olr419, Olr420, Olr421, Olr434, Olr808, OR1L1, OR1S1, OR3A1, OR5K1, PDZK1, PEPT1, Pilr-β2, R7BP, RENBP, S-antigen, SerpinA9, Skint2, SLC17A4, SLC22A11, SLC22A14, SLC22A23, SLC22A29, SLC22A9, SLC26A11, ST8Sia V, TMEM37, TMPIT, TRH-R2, V1RA5, V1RA6, V1RA9, V1RB1, V1RB4, V1RB7, V1RB8, V1rc3132, V1RD11, V1RI2, V2R11, Vasculin, Vmn1r101, Vmn1r118, Vmn1r139, Vmn1r15, Vmn1r152, Vmn1r157, Vmn1r17, Vmn1r184, Vmn1r196, Vmn1r30, Vmn1r34, Vmn1r61, Vmn1r86, Vmn1r88, Vmn2r100, Vmn2r103, Vmn2r114, Vmn2r32, Vmn2r45, Vmn2r55, Vmn2r59, Vmn2r67, Vmn2r76, Vmn2r77, Vmn2r81, Vmn2r98, VPS51, WNK1, and WNK3.Activator of:
Ace3, AGTRAP, ANG III, ANG IV, AT1, AT1a, AT2, ATP13A3, CPA4, CYP11B2, Cyp2c39, CYP2C9, CYP2J9, DDR2, Dear, dystrophin, ECSCR, ET-3, FAPα, FRG1B, GRK 3, hepcidin, Integrin α11, IRX4, KLHL3, KLK1_Klk1, LTBP-1, MAGP-1, MAS1, MKP-4, MYH6, Na+ CP type Iα, Na+ CP type IIIβ, NCCT, NHE-5, NHE-7, OATP-H, Podocin, Relaxin 1, Renin, Renin Receptor, Renin-1, SerpinA3b, SLC10A5, SLC22A12, SLC35E4, SLC45A4, SLC46A3, Sodium Chloride, V3R 11, and WNK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Losartan, 100 mg | sc-353662 | 100 mg | $130.00 |