Nur77 Activators
Nur77, also known as NR4A1, belongs to the nuclear receptor superfamily and plays a crucial role in regulating various cellular processes, including apoptosis, inflammation, and metabolism. The identified chemicals act as activators of Nur77 through distinct pathways, demonstrating the protein's versatility in responding to different cellular signals. Forskolin stimulates Nur77 activation through cAMP-dependent pathways, indicating the involvement of CREB-mediated transcriptional regulation. PMA induces Nur77 phosphorylation via the PKC-ERK/MAPK cascade, highlighting the intricate interplay between protein kinase activities. A23187 triggers Nur77 activation by elevating intracellular calcium levels, demonstrating the significance of calcium-dependent signaling in Nur77 regulation.
Dibutyryl cAMP and GW0742 exemplify the crosstalk between Nur77 and nuclear receptors, with cAMP/PKA and PPARβ/δ pathways influencing Nur77 expression, respectively. The potassium channel enhancer 4-aminopyridine showcases how ion channels can modulate Nur77 through calcium-dependent pathways. SB202190 and H89 underscore the role of kinases in Nur77 activation, with p38 MAPK and PKA inhibitors attenuating Nur77 phosphorylation. Thapsigargin-induced ER stress and Dimethyl Fumarate activation of Nrf2 demonstrate the integration of Nur77 into cellular stress response pathways. Calyculin A and A769662 highlight the importance of phosphatase inhibition and AMPK activation, respectively, in Nur77 regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an adenylate cyclase activator, stimulates cAMP production. Elevated cAMP levels activate PKA, leading to the phosphorylation and activation of Nur77 through a cAMP response element-binding protein (CREB)-dependent pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which subsequently phosphorylates Nur77. This activation is mediated through the ERK/MAPK pathway, where PKC activates ERK, leading to the phosphorylation and activation of Nur77. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 induces calcium influx and activates calmodulin-dependent pathways. Increased intracellular calcium levels activate calmodulin, leading to the phosphorylation and activation of Nur77 through calmodulin-dependent kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable analog of cAMP. It directly activates PKA, initiating a signaling cascade that results in the phosphorylation and activation of Nur77 through the CREB pathway. | ||||||
GW 0742 | 317318-84-6 | sc-203991 sc-203991A | 10 mg 50 mg | $190.00 $815.00 | 11 | |
GW0742 is a selective PPARβ/δ agonist. Its activation of PPARβ/δ leads to the upregulation of Nur77 expression through a PPARβ/δ-dependent mechanism. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $37.00 $1132.00 $120.00 | 3 | |
4-aminopyridine enhances potassium channel activity. Increased potassium efflux leads to membrane depolarization, activating voltage-gated calcium channels. Elevated intracellular calcium levels activate calmodulin-dependent kinases, ultimately leading to Nur77 phosphorylation and activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB202190 is a selective p38 MAPK inhibitor. Inhibition of p38 MAPK results in decreased Nur77 phosphorylation and activation, as p38 MAPK is involved in the signaling cascade that leads to Nur77 activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER stress by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump. ER stress triggers the activation of calcium/calmodulin-dependent kinases, leading to Nur77 phosphorylation and activation. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $27.00 | 6 | |
DMF activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Nrf2 activation induces the expression of Nur77 through an unknown but direct mechanism. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a protein phosphatase 1 and 2A inhibitor. Inhibition of these phosphatases results in sustained Nur77 phosphorylation and activation, as these phosphatases typically dephosphorylate and inactivate Nur77. | ||||||