Molecular structure of 4-Aminopyridine, CAS Number: 504-24-5
4-Aminopyridine (CAS 504-24-5)
See product citations (3)
Alternate Names:
4-Pyridinamine; Fampridine
Application:
4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane
CAS Number:
504-24-5
Purity:
≥98%
Molecular Weight:
94.11
Molecular Formula:
C5H6N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Aminopyridine (4-AP) is a nonselective K+ channel blocker that has been used to characterize and study the blockage of K+ channels. Studies show that 4-Aminopyridine binds from the cytoplasmic side of the cell membrane. Research suggests that 4-Aminopyridine extends the potentials of unmyelinated and demyelinated fibers, facilitates conduction in fibers blocked by demyelination, and can induce glutamate and neurotransmitter gamma-aminobutyric acid (GABA) release.
4-Aminopyridine (CAS 504-24-5) References
- Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. | Tseng, GN. 1999. J Pharmacol Exp Ther. 290: 569-77. PMID: 10411564
- (4-Aminopyridine-kappaN1)(phthalocyaninato-kappa4N)zinc(II) tetrahydrofuran disolvate. | Yang, FJ., et al. 2008. Acta Crystallogr C. 64: m375-7. PMID: 18989080
- [4-Aminopyridine (Fampridine). A new attempt for the symptomatic treatment of multiple sclerosis]. | Husseini, L., et al. 2010. Nervenarzt. 81: 203-11. PMID: 20112006
- Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS. | Westphalen, RI., et al. 2010. J Neurochem. 113: 1611-20. PMID: 20374421
- 4-aminopyridine: new life for an old drug. | Hauser, SL. and Johnston, SC. 2010. Ann Neurol. 68: A8-9. PMID: 20583227
- 4-aminopyridine and cerebellar gait: a retrospective case series. | Schniepp, R., et al. 2012. J Neurol. 259: 2491-3. PMID: 22760944
- 4-aminopyridine toxicity: a case report and review of the literature. | King, AM., et al. 2012. J Med Toxicol. 8: 314-21. PMID: 22782458
- Can 4-aminopyridine modulate dysfunctional gait networks in Parkinson's disease? | Luca, CC. and Singer, C. 2013. Parkinsonism Relat Disord. 19: 777-82. PMID: 23706539
- Restoring Axonal Function with 4-Aminopyridine: Clinical Efficacy in Multiple Sclerosis and Beyond. | Leussink, VI., et al. 2018. CNS Drugs. 32: 637-651. PMID: 29992409
- 4-aminopyridine is not just a symptomatic therapy, it has a neuroprotective effect - No. | Göbel, K. and Wiendl, H. 2020. Mult Scler. 26: 1311-1312. PMID: 32628061
- Neuroprotective Properties of 4-Aminopyridine. | Dietrich, M., et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8: PMID: 33653963
- Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. | Sherratt, RM., et al. 1980. Nature. 283: 570-2. PMID: 7354839
- Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. | Bouchard, R. and Fedida, D. 1995. J Pharmacol Exp Ther. 275: 864-76. PMID: 7473178
Inhibitor of:
Complexin-4, cytochrome b5, KCNA (Voltage-gated potassium (Kv) channels), KCNF1, KCNG1, KCNG2, KCNG3, KCNV1, KCNV2, KIR7.1, KVβ.1, KVβ.2, KVβ.3, KV1.3, KV1.7, KV3.1, KV4.2, KV4.3, KV6.3, KV9.3, MaxiKβ, Munc13-3, NKAIN4, Olfr370, Olfr790, Shaker, STOML2, TALK-2, THIK-2, TMEM38B, Trk1, TWIK-2, and TWIK-3.Activator of:
ABCA16, ATP10C, ATP8A2, CatSperβ, CatSperδ, CatSperγ, CatSper2, CD8α, GlyR α2, KChIP1, KCNC3, KCNC4, KCNG1, KCNG2, KCNH7, KCNRG, KIR4.2, KV1.1, KV1.2, KV1.3, KV1.4, KV1.6, KV2.2, KV3.1, KV3.2, KV4.1, KV9.2, LGICZ1, Myf-6, Na+ CP type IIα, NK-2R, Nur77, parvalbumin α, sodium channel type III, sodium channel type IV, SPACA4, SV2B, Synaptotagmin X, Syntaxin, TMEM150C, and VAMP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Aminopyridine, 25 g | sc-202421 | 25 g | $37.00 | |||
4-Aminopyridine, 100 g | sc-202421A | 100 g | $120.00 | |||
4-Aminopyridine, 1 kg | sc-202421B | 1 kg | $1132.00 |