NSE4A Inhibitors
NSE4A inhibitors are a category of chemical agents that interact with a specific protein known as Non-SMC Element 4 Homolog A (NSE4A), which is a component of the Structural Maintenance of Chromosomes (SMC) complex. This complex is essential for chromosome structure and dynamics, including processes such as chromosome condensation, segregation, and DNA repair. NSE4A inhibitors are designed to specifically bind to the NSE4A protein, influencing its interaction with other components of the SMC complex. By targeting NSE4A, these inhibitors can modulate the function of the entire complex, which plays a crucial role in maintaining the stability and integrity of the genome within the cell nucleus. The mechanism of action of NSE4A inhibitors involves the disruption of protein-protein interactions within the SMC complex, which can lead to a cascade of effects on cellular processes that rely on proper chromosome organization and maintenance.
The development of NSE4A inhibitors is based on the understanding of the molecular structure of the NSE4A protein and its interaction with other SMC components. Advances in structural biology and biochemistry have allowed researchers to map the binding sites and conformational changes that occur when NSE4A interacts with its partners within the complex. By designing molecules that can precisely target these interactions, NSE4A inhibitors can exert their influence on the SMC complex. The specificity of these inhibitors is critical, as it allows for the modulation of the NSE4A function without interfering with other unrelated cellular systems. The chemical properties of NSE4A inhibitors are varied, allowing for the exploration of different inhibitor families with distinct binding affinities, kinetics, and modes of action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that alters chromatin structure, leading to changes in gene expression. By changing the accessibility of DNA for transcription, Trichostatin A could indirectly inhibit NSE4A expression by affecting the transcription machinery necessary for its gene expression. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 inhibits the NEDD8-activating enzyme necessary for cullin-RING ligase function. Since NSE4A is part of the cohesion complex, its stability might be regulated by ubiquitination pathways. MLN4924 could indirectly inhibit NSE4A function by disrupting the protein degradation pathways that regulate the cohesin complex components. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA crosslinking agent that leads to DNA damage and inhibits DNA synthesis. As NSE4A plays a role in the repair of DNA during replication, the presence of DNA crosslinks created by Mitomycin C could indirectly inhibit the functional activity of NSE4A by overwhelming the repair mechanism. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR inhibitor VE-821 targets the ATR kinase which is critical for the DNA damage response. Since NSE4A is involved in the maintenance of genomic stability, inhibition of ATR could indirectly decrease the functional activity of NSE4A by reducing its recruitment or activity at sites of DNA damage. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a checkpoint kinase inhibitor that inhibits CHK1 and CHK2, key proteins in the DNA damage response. Inhibition of these kinases could reduce the efficacy of NSE4A in the DNA damage repair process by disrupting the signaling events leading to its activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of Phosphoinositide 3-kinases (PI3K), which are involved in cell growth and survival signaling. By inhibiting PI3K, Wortmannin could indirectly inhibit NSE4A by disrupting the cellular signals that facilitate its role in maintaining genomic integrity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD 0332991, also known as palbociclib, is mentioned earlier in this table with its function as a CDK4/6 inhibitor and its potential indirect effect on NSE4A function through cell cycle arrest. | ||||||
RG-7112 | 939981-39-2 | sc-507292 | 10 mg | $520.00 | ||
RG7112 is an MDM2 antagonist that activates p53, leading to cell cycle arrest and apoptosis. As the cohesin complex, which includes NSE4A, is important for cell division, activation of p53 by RG7112 could indirectly inhibit NSE4A by halting the cell cycle before cohesin complex function is required. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a PARP inhibitor exploiting defects in DNA repair mechanisms. Since NSE4A is involved in chromosome segregation and DNA repair, inhibition of PARP could indirectly inhibit NSE4A function by interfering with the DNA repair pathways where NSE4A may play a role. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that prevents the re-ligation step of DNA during replication and transcription, causing DNA damage. Since NSE4A is implicated in DNA repair, camptothecin could indirectly inhibit NSE4A by increasing the DNA repair load beyond the capacity of the cohesin complex. | ||||||