NP220 Inhibitors
NP220 inhibitors are a class of chemical compounds that specifically target the NP220 protein, also known as ZMYND11. This protein plays a crucial role in chromatin remodeling and transcriptional regulation, particularly in the context of gene silencing. NP220 is involved in the recruitment of chromatin-modifying enzymes and transcriptional repressors to specific genomic loci, thereby regulating gene expression patterns. By inhibiting the activity of NP220, these inhibitors have the potential to alter gene expression profiles in cells, leading to downstream effects on cellular function and phenotype.
The development of NP220 inhibitors represents a promising area of research in the field of chemical biology and epigenetics. Understanding the molecular mechanisms of NP220 function and inhibition could provide valuable insights into gene regulation and chromatin dynamics. Additionally, NP220 inhibitors have the potential to be used as tools in the study of epigenetic mechanisms and gene expression control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As an HDAC inhibitor, Trichostatin A prevents the removal of acetyl groups from histones. If NP220 is involved in or affected by chromatin structure and compactness, Trichostatin A could indirectly modulate its function or expression through chromatin relaxation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine disrupts DNA methylation by trapping DNA methyltransferases. If NP220's function or expression is influenced by DNA methylation patterns, this compound could affect it indirectly. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin selectively inhibits the proteasome's chymotrypsin-like activity. If NP220 undergoes proteasomal degradation or if its function is tied to proteins that do, Epoxomicin could stabilize NP220 or its interacting partners. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases, leading to increased phosphorylation of numerous proteins. If NP220 function or stability is modulated by phosphorylation, Calyculin A could indirectly affect NP220 activity. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
By inhibiting histone acetyltransferases, Anacardic Acid reduces histone acetylation. If NP220 interacts with or is regulated by histone acetylation, its function or expression could be indirectly modulated. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro 31-8220 is a PKC inhibitor. If NP220 is involved in signaling pathways that are PKC-dependent, its activity or interactions might be influenced by this inhibitor. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
By inhibiting eIF2α dephosphorylation, Salubrinal affects protein translation. If NP220's synthesis or function is linked to eIF2α-mediated translation, this compound could indirectly modulate its levels or activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide targets topoisomerase II, affecting DNA topology. If NP220 has functions associated with DNA structure or repair mechanisms affected by topoisomerase II, it might be indirectly modulated by Etoposide. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a bromodomain inhibitor, specifically against BRD4. If NP220's function is linked to reading of acetylated histones through bromodomains, its activity could be indirectly affected by JQ1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine inhibits CDKs, impacting cell cycle progression. If NP220 has a role in the cell cycle or if its function is tied to CDK activity, Roscovitine can indirectly influence it. | ||||||