Notch 1 Activators
Notch 1 Activators are a class of chemical compounds that specifically aim to enhance the activity of the Notch 1 signaling pathway. The Notch 1 pathway is an evolutionarily conserved cell signaling system that plays a critical role in controlling various cellular processes, including cell fate determination, proliferation, and differentiation. Activation of this pathway generally begins with ligand-receptor interactions on adjacent cells, followed by proteolytic cleavages of the Notch 1 receptor. These cleavages release the intracellular domain of the Notch 1 protein (NICD), which then translocates to the nucleus to regulate the expression of target genes. Compounds in this category usually facilitate these processes, either by directly interacting with Notch 1 components or by modulating the cellular environment in a manner that favors Notch 1 activation.
The mechanisms by which Notch 1 Activators function can be quite diverse. Some compounds act by mimicking natural ligands that bind to the Notch 1 receptor, thereby initiating the signaling cascade. Others may affect the post-translational modification of Notch 1 or its interacting proteins, effectively fine-tuning the activation process. Additionally, some activators may work indirectly by inhibiting negative regulators of the Notch 1 pathway. It's worth noting that these activators can come from various chemical classes, such as small organic molecules, natural products, and synthetic compounds, each with their unique structure-activity relationships.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, is known to regulate cell differentiation and proliferation. It has been reported to upregulate Notch 1 expression by acting on retinoic acid receptors, which may subsequently modulate gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a bioactive compound found in turmeric, can potentially upregulate Notch 1 through its effects on oxidative stress and NF-κB pathways, although the precise mechanisms remain to be elucidated. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in red wine and grapes, is thought to induce Notch 1 expression potentially by activating SIRT1, which may in turn affect cellular signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, may induce Notch 1 expression by inhibiting histone deacetylases, thereby affecting chromatin structure and gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that may increase Notch 1 expression by reducing methylation of its gene promoter, thus enhancing its transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, is proposed to upregulate Notch 1 potentially through antioxidant activity and modulating intracellular signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone found in soy products, has been reported to induce Notch 1 expression potentially by inhibiting protein tyrosine kinases and affecting downstream signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine may enhance Notch 1 expression through the inhibition of phosphodiesterase, thereby increasing cAMP levels which might indirectly affect Notch signaling. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol, found in cruciferous vegetables, may affect Notch 1 expression through its ability to modulate estrogen receptor pathways, although the specific mechanisms are still under investigation. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid is proposed to induce Notch 1 expression by inhibiting cyclooxygenase enzymes, which may lead to altered cellular signaling cascades. | ||||||